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《Journal of Southwest University(Natural Science Edition)》 2009-01
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Association Between Genetic Polymorphism of ET-1 and Hypertensive Ischemic Stroke

HANG Li-wei1,ZHOU Jian-zhong1,WANGZhen1,DOU Gui-wang1,ZHONG Wang-tao2,WU Zhi-hong21. Chongqing Medical University,Chongqing 400016,China;2. Hospital Guangdong Medical College,Zhanjiang Guangdong 524001,China  
Objective:To evaluate the correlation between the polymorphism of Lys198Asn and TaqI of ET-1 (Endothelin-1) gene and hypertensive ischemic stroke. Methods:Polymorphism distribution of Lys198Asn and TaqI was detected in 46 patients with hypertensive ischemic stroke and 50 hypertension controls by SSP-PCR and PCR-RFLP. Results:The genotype distribution of Lys198Asn and TaqI of controls was in Hardy-Weinberg equilibrium. A significant difference was present in frequencies of genotype and allele in Lys198Asn polymorphism between the hypertensive ischemic stroke group and the control group (p0.05). The relative risk of suffering from ischemia stroke with T allele carrier was 4.855 times that with GG genotype (OR=4.855,95%CI:2.197-16.608). There was no significant difference in frequencies of genotype (p0.05) and marginally significant difference existed in frequencies of allele (p=0.04) in TaqI polymorphism between the hypertensive ischemic stroke and the control groups. The odds ratio for those exposed to GG (Lys198Asn) + GG (Taq I) genotype was 0.091,95% confidence interval was 0.01-0.84,p=0.035. Conclusion:T allele of Lys198Asn may be a risk factor for hypertensive ischemic stroke. TaqI may have a synergistic effect with Lys198Asn polymorphism.
【Fund】: 重庆市科委自然科学基金资助项目(CSTC 2006BB5044)
【CateGory Index】: R743.3
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