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《Journal of Xianning College(Medical Sciences)》 2010-01
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Expression and Significance of c-Jun N-terminal Kinase in Necrotizing Enterocolitis of Neonatal Rats

XI Juan-li,LIU Xian-zhou(Wuhan University Medical School,Wuhan Hubei 430071,China)  
Objective To investigate the intracellular distribution and role of c-Jun N-terminal Kinase(JNK) in hypoxia-induced neonatal rat necrotizing enterocolitis(NEC).Methods Newborn Wistar rats were divided randomly into experimental group and control group,10 rats in each group.After NEC model was established,they were returned to their mothers.Rats were killed on day 4,and distal ileum was harvested for morphological study and immunohistochemistry for JNK.Results In normal intestinal tissue,there is no or only very weak staining for phosphorylation of JNK protein.Compared with control group,the expression of JNK was significantly increased and began to translocate from cytoplasm to nucleus in NEC group.Conclusion JNK signal pathway might play important role in the pathogenesis of NEC.
【CateGory Index】: R722.1
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Yuan Yong1,Guo Hao2,Zhang Yi1,Gan Ping1,Zhou Dong1,Chen Jiayong1(1.Department of Emergency,the Second Affiliated Hospital of Kunming Medical College,Kunming 650101,China;2.Department of Cardiology,Calmette Hospital,Kunming Medical College,Kunming 650011,China);Protective effect of ischemic postconditioning on the intestinal ischemia-reperfusion in rats[J];Chongqing Medicine;2011-24
2 YANG Hai-bo1,ZHANG Jing-zhe2,CAI Jun2,ZHANG Xue-lin2,SONG Hua-rong2 (1.Department of Colorectal Surgery,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China;2.Department of General Surgery,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China);Protective effect of Rhubarb and early enteral nutrition on intestinal mucosal barrier injury after ischemia-reperfusion in rats[J];Parenteral & Enteral Nutrition;2011-06
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7 Wang Dan(Department of Pediatrics,Maternal and Child Health Care Center of Dongxihu District,Wuhan,Hubei 430040,China);The detection on serum level of β-glucosidase in neonatal necrotizing enterocolitis and its significance[J];Chongqing Medicine;2012-32
8 Chen Yang,Xia Shiwen,Song Fei,Zhang Yi(Hubei Province Maternal and Child Health Hospital,Hubei Wuhan 430070,China);Neonatal Necrotizing Enterocolitis: A Clinical Analysis of 26 Cases[J];Journal of Pediatric Pharmacy;2013-03
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10 LIU Ke-xuan,HUANG Wen-qi;Protective effects of preconditioning and postconditioning against the intestines I/R injury[J];China Continuing Medical Education;2010-04
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