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《Journal of Xianning College(Medical Sciences)》 2010-01
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The Expression of P53 Gene in Nasopharyngeal Carinoma

HONG Li,WU Li-lian,HU Yan-min(The Second Affiliated Hospital,Xianning University,Xianning Hubei 437100,China)  
Objective To study the relationship between the expression of P53 protein and the main clinical characteristics of the patients with nasopharyngeal carcinoma(NPC).Methods Immuuohistochemistry technique was used to test the expression of P53 protein in 54 cases of NPC specimens and 13 cases of chronic inflammation of nasopharoyngeal epithelium(CINE) specimens.Results The positive expression rate of P53 protein in NPC specimens was 75.9%,which was obviously higler than that in CINE(7.7%)(P0.01).The expression of P53 protein was significantly related to metasfases of cervical lvmph node in NPC(P0.01).Condusion The expression of P53protein is high in NPC,which was associated with increasion of tumor dissemination and metasfases.
【CateGory Index】: R739.63
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