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《Journal of Xianning University(Medical Sciences)》 2012-01
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Relationship between Tissue Inhibitor of Metalloproteinases-2 Gene Polymorphism and Protein Expression of Tissue Inhibitor of Metalloproteinases-2

WANG Wei,XU Min(Department of Internal Medicine,Xianning University,Xianning Hubei 437100,China)  
Objective To study the relationship between TIMP-2 gene polymorphism and protein expression of TIMP-2.Methods Methods The single nucleotide polymorphism of position +853 of the TIMP-2 gene was revealed in 29 pulmonary tissues without pathological changes by polymerase chain reaction-restriction fragment length polymorphism.Immunohistochemical method was used for the detection of protein expression of TIMP-2 in pulmonary tissues.Association between the single nucleotide polymorphism of TIMP-2 gene at position +853 and protein expression of TIMP-2 was analyzed.Results At position+853,the genotype frequencies were 51.7% for G/G,31% for G/A,and 17.3% for A/A.Protein expression of TIMP-2 was not significantly different in three genotypes by semiquantitative detection and quantitate detection(P0.05).Conclusion TIMP-2 gene polymorphism at position+853 does not change protein expression of TIMP-2.
【CateGory Index】: R563.9
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