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《Southwest China Journal of Agricultural Sciences》 2008-01
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Study on the immunopathology of piglets infected with PRRSV and PRRSV/PCV2

WANG Tian-hu,LOU Zhong-zi,LIU Si-dang*(College of Animal Science and Veterinary Technology,Shandong Agricultural University,Shandong Tai'an 271018,China)  
40-day-old piglets were infected by PRRSVand PRRSV/PCV2 to establish a pathological model.It was used in order to compare the pathological changes of immune organs and peripheral blood lymphocytes which were induced by the two kinds of infection models.The result indicates that both PRRSV and PRRSV/PCV2 infection could cause augment of immune organs index.The most of the immune organ indexes of co-infection were higher than mono-infection group.Pathohistological survey indicates that it was acute exudation and chronic granulomatous inflammation not lymphadenosis that induced the augment of immune organ index.Fortonsil,spleen and the main peripheral lymphoid nodes of the test piglets,dynamic pathohistological survey indicates that monoinfection caused by PRRSV could induces acute inflammation of immune organs,the inflammation was characterized by degeneration and necrosis of lymphocyte and macrophage and could induce immunosuppression.The co-infection by PRRSV/PCV2 not only worsens the lesion but also induces lymphatic folliculus deletion in spleen and granulomatous inflammation of lymphoid nodes.Apoptosis of cells in lymph,lung,spleen and liver were detected by electron microscope and terminal deoxynucleotidyl transferase UIP nick end labeling(TUNEL) on the piglets.The results showed PRRSV and PRRSV/PCV2 infection could induce incoordinate apoptosis of cells in above organs.And the lymphocyte apoptosis were seriously in spleen,lymph and lung.These organs appeared apoptosis in earlier time and necrosis of lymphocytes in later time,being seriouser in the piglets infected with PRRSV/PCV2.So the apoptosis in earlier time and necrosis of lymphocytes in later time was one of the cause of immunorepression on the piglets.
【CateGory Index】: S858.28
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