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《中国药学(英文版)》 2003-02
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Comparative Efficacy and Distribution of Evans Blue Liposome Modified with DSPE-PEG,Tween80,and Brij35

ZHANG Xiao bin and HOU Xin pu *(Department of Physical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China)  
Aim To improve the stability and optimize the tissue distribution of Evans blue liposome in rats, some surfactants such as DSPE PEG, Tween80, and Brij35 were used to modify the Evans blue liposome. Methods The Evans blue liposome was prepared by the reverse phase evaporation method. The effect of cholesterol on the encapsulation percentage of Evans blue was studied. The effects of DSPE PEG, Tween80, and Brij35 on the encapsulation percentage and tissue distribution of Evans blue liposome in the rat were determined. Results The top encapsulation percentage of Evans blue liposome is 25 30%. After modification by DSPE PEG, Tween80, and Brij35, the encapsulation percentages decreased slightly, but not significantly. After modification, the Evans blue concentrations deceased in the liver, spleen, lung and kidney, but increased in the brain, especially in the EB L Tween80 group. Conclusion DSPE PEG, Tween80, and Brij35 have slight effect on the encapsulation percentage of Evans blue liposome. The effect of Brij35 on the distribution of Evans blue liposome is similar to that of DSPE PEG because they both is prevent the reticuloendothelial system (RES) from clearing liposome. The Evans blue concentration in the brain is greatly improved when Tween80 is used to modify the EB liposome, which is good information for preparing liposome targeting the brain.
【Fund】: Supportedbythenationalnaturalsciencefundofchina No .3 0 171114
【CateGory Index】: R94
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【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Guo Juanjuan,Pan Xianglin,Feng Changwei,Zou Junhui (The Affiliated Hospital of Shandong Medical University,Jinan 250012,China);EFFECTS OF ORIDONIN ON INDUCING THE MULTI-DRUG RESISTANT CELL LINE K562/A02 TO APOPTOSIS AND REVERSING THEIR MULTI-DRUG RESISTANCE[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;2000-03
2 Wang Mian-ying and zhang Tan-mu Department Pharmacology, Henan Medical Research Institute, Zhengzhou;STUDY OF THE MECHANISM OF ACTION OF RUBE SCENSINE A ON M PHASE OF SEVERAL TUMOR CELLS[J];Chinese Journal of Cancer;1984-02
3 Feng Changwei; Pan Xianglin; Zou Junhui; et al (the Affiliated Hospital of Shandong Medical University, Jinan 250012);Study on Inhibition of Human HL-60 Cell Growth by Oridonin[J];JOURNAL OF ZHEJIANG COLLEGE OF TCM;2000-03
4 Li Qi, Chen Zheng Department of Pharmacology;EFFECT OF ORIDONIN ON BINDING CAPACITY OF β-ADRENERGIC RECEPTOR AND ACTIVITY OF ADENYLATE CYCLASE[J];;1991-02
5 ZHANG Xiao-Bin, WANG Xiang-Tao, LI Sha,HOU Xin-Pu △ (Department of Pharmaceutics,Peking University School of Pharmaceutical Sciences, Beijing 100083, China);Preparation of the liposomes containing Evens blue and its distribution in mice[J];Journal of Beijing Medical University;2002-04
6 YANG Cai-qin~*, WANG Wei ,ZHAN Wen-hong (College of Pharmacy ,Hebei Medical University, Shijiazhuang 050017);Study on the Enhancing Solubility of HP-β-CD with Gliclazide by Phase Solubility Method[J];Journal of Analytical Science;2004-03
7 Zhao Wei Harbin No.6 Phamaceutical Factory(150056);The New Method for Preparing Oridonin by Medium Pressure Column Chromatography[J];Heilongjiang Medical Journal;2001-01
8 Shou Magang, et al Department of pharmacology, Henan Medical Institute;Study of the effet of oridonin and bleomycin A_5 combination therapy on the cell cycle of Ehrlich carcinoma cells by means of the flow cytometry[J];;1985-02
9 Wang Mianying, et al Department of pharmacology, Henan Medical Research Institute;Microphotometric and autoradiographic studies of cytokinetic effects of oridonin on L_(1210) and S_(180) cells[J];;1986-01
10 Yang, Yan-Wu Xu, Xiao-Long~* Wang, De-Hua Qian, Bao-Gong (Laboratory of Magnetic Resonance and Atomic and Molecular Physios, Wuhan Institute of Physics, Academia Sinca, Wuhan 430071) Zhao, Qing-Zhi Ji, Ang (Department of Chemistry, Henan University of Medical Science, Zhengzhou, 450053);Studies of Molecular Configuration of Oridonin by 2D-NMR[J];Acta Chimica Sinica;1992-05
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 CHEN Mei-wan,CHEN Rui-e,LI Ying-bo,TAN Wen,WANG Yi-tao (Institute of Chinese Medical Sciences,State Key Laboratory of Quality Research in Chinese Medicine, University of Macau,Macau 999078,China);Research and Application in Nanoparticle Formulation of Oridonin[J];Chinese Journal of Experimental Traditional Medical Formulae;2011-16
2 GAO Huan,GAO Qi,WANG De-yun,FAN Yun-peng,GUO Li-wei,ZHAO Xiao-na(Institute of Traditional Chinese Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,China);Preparation Conditions Optimization of Epimedium Polysaccharide Liposome[J];Journal of Chinese Medicinal Materials;2011-09
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