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《Journal of Modern Medicine & Health》 2013-11
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Clinical observation on effects of different doses of polyene phosphatidylcholine injection in treating liver fibrosis

Lin Chunlan,Zhang Ning,Li Rui,Chen Weigang,Zheng Yong(Department of Gastroenterology,First Affiliated Hospital,Medical College of Shihezi University,Shihezi,Xinjiang 832000,China)  
Objective To investigate the clinical efficacy differences among different doses of the polyene phosphatidylcholine injection(Essentiale) in the treatment of patients with hepatic cirrhosis.Methods 60 patients with hepatic cirrhosis enrolled in the gastroenterology department from April 2011 to August 2012 were collected and randomly assigned to the treatment group(n=30) treated with high-dose Essentiale 20 mL by intravenous drip and the control group(n=30) treated with low-dose Essentiale10 mL by intravenous drip.The efficacies before and after treatment were observed and compared between the two groups.Results After treatment,the liver function was improved in both groups(bilirubin,aminotransferase and cholesterol were lower than before treatment),serum fibrosis markers were reduced and hemagglutination indicators were improved,meantime the improvement in the high-dose group was more significant than that in the low-dose group,the differences had statistical significance(P0.05).Conclusion Essentiale has the obvious effect to repair damaged liver cells and improve liver fibrosis,moreover,high-dose Essentiale has more obvious effect and is worthy of promotion.
【CateGory Index】: R575.2
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