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《Journal of Modern Medicine & Health》 2013-11
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Clinical observation on effects of different doses of polyene phosphatidylcholine injection in treating liver fibrosis

Lin Chunlan,Zhang Ning,Li Rui,Chen Weigang,Zheng Yong(Department of Gastroenterology,First Affiliated Hospital,Medical College of Shihezi University,Shihezi,Xinjiang 832000,China)  
Objective To investigate the clinical efficacy differences among different doses of the polyene phosphatidylcholine injection(Essentiale) in the treatment of patients with hepatic cirrhosis.Methods 60 patients with hepatic cirrhosis enrolled in the gastroenterology department from April 2011 to August 2012 were collected and randomly assigned to the treatment group(n=30) treated with high-dose Essentiale 20 mL by intravenous drip and the control group(n=30) treated with low-dose Essentiale10 mL by intravenous drip.The efficacies before and after treatment were observed and compared between the two groups.Results After treatment,the liver function was improved in both groups(bilirubin,aminotransferase and cholesterol were lower than before treatment),serum fibrosis markers were reduced and hemagglutination indicators were improved,meantime the improvement in the high-dose group was more significant than that in the low-dose group,the differences had statistical significance(P0.05).Conclusion Essentiale has the obvious effect to repair damaged liver cells and improve liver fibrosis,moreover,high-dose Essentiale has more obvious effect and is worthy of promotion.
【Key Words】: Phosphatidylcholines/therapeutic use Liver cirrhosis/therapy Different doses Polyene phosphatidylcholine
【CateGory Index】: R575.2
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 WANG Jun,ZHAO Quan,LU Ying,et al.Dept.of Medical Examination,the 401st Hospital of PLA,Qingdao,Shandong 266071,China;Clinical evaluation on the diagnosis value of LN level in serum for hepatic fibrosis[J];Practical Journal of Medicine & Pharmacy;2011-02
2 LU Lun-gen, ZENG Min-de. Department of Gastroenterology, Renji Hospital, Shanghai Institute of Digestive Diseases, Shanghai Second Medical University, Shanghai 200001, China;Diagnosis and evaluation of hepatic fibrosis[J];Chinese Journal of Hepatology;2005-08
3 HU Guoping, LIU Kai, ZHAO Liansan Key Laboratory of Infectious Disease Molecular Biology of Sichuan Province. Key Laboratory of Biotherapy of Human Disease Ministry of Education, P.R. China. Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, 610041 China;Polyunsaturated phosphatidylcholine (Essentiale) for alcoholic/fatty liver:A systematic review[J];Chinese Hepatology;2005-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 GUAN Wen-jie,LV Xiong-wen,YANG Wan-zhi,DAI Xue-fei,LI Jun (School of Pharmacy,Anhui Medical University,Hefei 230032,China);Research progress of treatment of alcoholic liver disease[J];Anhui Medical and Pharmaceutical Journal;2011-08
2 Zhu Liang TCM Hospital of Jingjiang City,Jingshu Province(214500);Huayu Xiezhu Decoction Treat Non-alcoholic Fat Hepatitis 45 Cases[J];Journal of Zhejiang University of Traditional Chinese Medicine;2007-05
3 JIANG Fei-fei, WANG Wen-jing, ZHAO Xiu-ying, et al (Department of Clinical Laboratory, Beijing You'an Hospital, Capital Medical University, Beijing 100069);Application analysis on detection of four serum indicators with a domestic chemiluminescence reagent in liver fibrosis diagnosis[J];Beijing Medical Journal;2012-03
4 LIANG Yi-zhen,ZHANG Yan,WANG Xiao-bai Radiology Department,The First Affiliated Hospital of Jinan University,Guangzhou,510630,China;Liver reserve function assessment peri-TACE and investigation on the correlated index[J];Contemporary Medicine;2010-11
5 ;健脾化浊方治疗非酒精性脂肪性肝炎临床研究[J];Contemporary Medicine;2010-21
6 ;探讨阿德福韦酯联合双虎清肝颗粒抗肝纤维化指标肝纤四项复常率[J];Contemporary Medicine;2012-07
7 Fattly Liver and Alcoholic Liver Disease Study Group of the Chinese Liver Disease Association.;Guidelines for diagnosis and treatment of nonalcoholic fatty liver diseases[J];Journal of Clinical Hepatology;2007-01
8 Fatty Liver and Alcoholic Liver Disease Study Group of the Chinese Liver Disease Association.;Guidelines for diagnosis and treatment of alcoholic liver diseases[J];Journal of Clinical Hepatology;2007-01
9 SHI Jun-ping1,FAN Jian-gao2 (1. Hangzhou Sixth Hospital,Zhejiang University of Traditional Chinese Medicine,Hangzhou 310014; 2. Department of Gastroenterology,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200092,China);Effects of hepatoprotectants in the treatment of nonalcoholic fatty liver disease[J];World Clinical Drugs;2010-09
10 CHEN Jie,CHEN Xin_yue. VIP Ward for Liver, Beijing Youan Hospital Affiliated to Capital University of Medical Sciences, Beijing 100069, China;Progress of researches on hepatic fibrosis' diagnosis[J];International Journal of Epidemiology and Infectious Disease;2006-06
China Proceedings of conference Full-text Database 1 Hits
1 Hospital of Jiangxi Medical College of Gastroenterology Xiongming Fang,Han Yubin~1,Hu Jia~1, Wang Liping,Xie Hui group~ 2,Xu Yun~ 2,Amateur Training~2,key wind Mei,Yang Satellite.;Softening Hard removing blood stasis of schistosomiasis cirrhosis Affiliated[A];[C];2010
【Secondary Citations】
Chinese Journal Full-text Database 9 Hits
1 WANG Sheng~1,HOU Yuan~2,LIU Zhong-hui~2 (1.The First Hospital of Jilin University,Changchun 130021,China;2.Basic Medical School of Jilin University,Changchun 130021,China);Clinical evaluation on detection of Type Ⅳ Collagen in serum of patients with liver disease[J];Jilin Medical Journal;2007-01
2 JIA Jidong, YIN Shanshan.Center of Liver Disease, Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050,China;Diagnosis and treatment of liver fibrosis[J];Journal of Clinical Internal Medicine;2002-04
3 YANG Shun,XIAO Yan,LIN Jun,YANG Huan,ZHU Xue-ming(Dept of Clinical Laboratory,the Second Hospital Affiliated to Suzhou University, Jiangsu Suzhou 215004,China);The Study on Serologic Index of Hepatic Fibrosis in Viral Hepatitis[J];Suzhou University Journal of Medical Science;2008-03
4 ZHENG Min, CAI Weiming, WENG Honglei, et al. Institute of Infectious Diseases, First Affiliated Hospital, School of Medicine,Zhejiang University, Hangzhou, Zhejiang 310003,China;ROC curve in evaluation of serum fibrosis index for diagnosing hepatic fibrosis[J];Chinese Journal of Infectious Diseases;2002-04
5 LI Chengzhong, WAN Mobin, ZENG Minde, et al. Changhai Hospital, Second Military Medical University, Shanghai 200433, China [;A preliminary study of the combination of noninvasive parameters in the diagnosis of liver fibrosis[J];Chinese Journal of Hepatology;2001-05
6 LU Lun-gen, ZENG Min-de. Department of Gastroenterology, Renji Hospital, Shanghai Institute of Digestive Diseases, Shanghai Second Medical University, Shanghai 200001, China;Diagnosis and evaluation of hepatic fibrosis[J];Chinese Journal of Hepatology;2005-08
7 Yao Jilu Gao Zhiliang Peng Xiaomao Zhou Yanping Li Gang Chong Yutian Deng Zhide He Youcheng Ke Weiming Lu Weilun (Hepatitis Institute, Depatment of Infectious Diseases, The Third Affiliated Hospital, Sun Yat sen University of Medical Scien;Basis and Applied Study of Clinical Diagnosis and Treatment on Viral Hepatitis[J];ACADEMIC JOURNAL OF SUN YAT-SEN UNIVERSITY OF MEDICAL SCIENCES;1999-01
8 LU Lungen, ZENG Minde, WAN Mobin, et al. Zha Bei Qu Central Hospital, Shanghai 200070;A preliminary study on the grading and staging of hepatic fibrosis, and its relations with noninvasive diagnostic parameters[J];Chinese Hepatology;2000-04
9 LI Xin, ZHANG Li-xin, CHEN Ya-bao, XIAO Wei Taizhou People’s Hospital, Taizhou 225300, China;Study on the correlation between serological indicators of hepatic fibrosis and PAPP and hepatic fibrosis[J];Chinese Medicinal Biotechnology;2009-05
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