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《Hereditas(Beijing)》 2005-01
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Detection of Major Gene on Litter Size in Sheep

WANG Qi-Gui~1, ZHONG Fa-Gang~2, LI Hui~1, WANG Xin-Hua~2, LIU Shou-Ren~2, CHEN Xiao-Jun~2, GAN Shang-Quan~2(1.College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030,China;2.Institute of Animal Husbandry and Veterinary Medicine, Xinjiang Academy of Agricultural Reclamation, Shihezi 832000,China)  
The current study was designed to detect SNPs within BMP15 and BMPR-IB gene and investigate the effect of the genes on sheep litter size.Four sheep lines, HU-Yang, Chinese Merino monotocous, Chinese Merino multiparous for wool production and Chinese Merino multiparous for mutton production, were used in this study.Litter sizes were recorded for each ewe in the four lines.Primers for BMP15 and BMPR-IB gene were designed from database sheep sequence and polymorphisms were detected by PCR-RFLP method.The results showed that there was no polymorphism with BMP15 gene among the four lines, and there was an A / G SNP with BMPR-IB gene at base 746 among the four lines.Three types of genotype (BB, B+ and ++), based on A / G locus, were found within each line.The frequencies of genotypes were significantly different among the lines (P0.001), with BB genotype primarily existing in HU-Yang, ++ genotype in Chinese Merino monotocous line, and B+ genotype in Chinnese Merino multiparous lines.The A / G mutation influence significantly the sheep litter sizes, and the BB and B+ ewes had significant higher litter sizes than ++ ewes.The results of present study showed simultaneously that the genotype of BMPR-IB was a perfect predictor of the sheep litter sizes.These results intensively indicated that BMPR-IB is a major gene to affect litter size in sheep, and could be used as the molecular genetic marker to select litter size in sheep.
【Fund】: 新疆生产建设兵团博士资金项目(2002-01);; 黑龙江省杰出青年基金项目(JC-02-06)~~
【CateGory Index】: S826.2
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