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《Hereditas(Beijing)》 2005-01
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Progress in Detection Methods of Single Nucleotide Polymorphisms

ZHAO Guang-Rong~1, YANG Fan~1, YUAN Ying-Jin~1, GAO Xiu-Mei~2, ZHANG Jun-Ping~2(1. Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, TianjinUniversity, Tianjin 300072, China; 2. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China)  
Single nucleotide polymorphism (SNP) is the third generation genetic marker. SNP detection now is becoming increasingly important means in molecular diagnostics, clinical assay and novel drug development. It plays an essential role in drug resistance and anaphylactic reaction and has the importamce in theoretical studies of gene location, hereditary diseases and human origin.The methods for SNP detection were renewed rapidly and developed fast in past few years. In this review, several newly established detection methods including gene chip, molecular probe, fluorescence polarization and resonance, mass spectrometry, and bacterial magnetic particle are discussed. It could be expected that an accurate and sensitive, simple and easy-to-handle SNP technology with low cost and high throughput will be available on the basis of research breakthroughs of biochemistry, engineering and analytic software.
【Fund】: 国家自然科学基金资助(30371712)~~
【CateGory Index】: R346
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