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《Hereditas(Beijing)》 2005-03
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Mechanisms of Epigenetic Reprogramming in Mammalian Reconstructed Embryos Produced by Nuclear Transfer

XU Shi-Jing, XU Yin-Xue, LIU Hong-Lin(College of Animal Science, Nanjing Agricultural University, Nanjing 210095,China)  
Circumstantial studies indicated that incomplete or inappropriate epigenetic reprogramming of donor nuclei was likely to be the primary reason for failures in nuclear transfer. In this view, we discussed the roles of several epigenetic mechanisms, including DNA methylation, chromatin remodeling, imprinting and X chromosome inactivation, (telomere) maintenance, and epigenetic inheritance in the observed abnormalities in clones from different species. Understanding the mechanisms underlying epigenetic reprogramming control will help us resolve the inherent problems in (nuclear) transfer technology and make its applications promising.
【Fund】: 国家自然科学基金“组蛋白去乙酰化对小鼠核移植胚基因组重序的调控”主题项目资助(编号:30371034)~~
【CateGory Index】: Q813
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