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《Hereditas(Beijing)》 2005-03
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Advances in Detection Technologies of in vivo Expression of Bacterial Virulence Gene

CHEN Shi-Yong~(1,2), MO Zhao-Lan~1, ZHANG Zhen-Dong~1, ZHOU Yu-Xia~1,XU Yong-Li~1, ZHANG Pei-Jun~1(1. Experimental Marine Biology Laboratory, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; 2. College of Life Science of Beijing University, Beijing 100871, China)  
The interactions between bacterial pathogens and their hosts are complex. To deepen our understanding of the pathogenesis of bacterial pathogens, it is necessary to identify bacterial virulence genes that are specifically induced in vivo during infection and probe their regulation in vivo. Toward this end, several technologies, such as in vivo expression technology (IVET), signature-tagged mutagenesis (STM), differential fluorescence induction (DFI), genomic analysis and mapping by in vitro transposition (GAMBIT) and in vivo induced antigen technology (IVIAT), have been developed. The purpose of this review is to update the reader on the many advances of these technologies, and to discuss their advantages and disadvantages.
【Fund】: 国家“973”重点基础研究专项经费(编号:G1999012003)资助~~
【CateGory Index】: Q786
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