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《Hereditas》 2008-09
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Polymorphism of 22 Y-STR loci in Guangdong Han population and genetic relationship with 12 populations

SHI Mei-Sen1, BAI Ru-Feng1, YU Xiao-Jun2, TANG Jian-Pin3 1. Key Laboratory of Evidence Science (China University of Political Science and Law), Ministry of Education, Beijing 100088, China; 2. Department of Forensic Medicine, Shantou University Medical College, Shantou 515041, China; 3. Department of Forensic Medicine, Guangdong Medical College, Dongguan 523808, China  
To investigate the genetic polymorphisms of 22 Y-chromosomal short tandem repeats(STR) loci in Guangdong Han population, and to evaluate their forensic application values and genetic relationships with 12 other populations. These Y-STR loci (DYS19, DYS389Ⅰ/Ⅱ, DYS390, DYS391, DYS392, DYS393, DYS385, DYS437, DYS438, DYS439, DYS461, DYS481, DYS504, DYS505, DYS508, DYS533, DYS576, DYS588, DYS607, DYS634, and DYS643) were analyzed in 216 unrelated healthy Guangdong Han individuals by three multiplex PCR systems including the PowerPlex Y System. Cluster analysis and phylogenic trees were applied to show the genetic distance among the populations. As a result, a total of 214haplotypes were identified and the overall haplotype diversity for the 22 Y-STR loci was 0.9999. The gene diversity values (GD) for each locus ranged from 0.3299 (DYS634) to 0.9425 (DYS385). Comparing with 12 other populations, the genetic distance between Guangdong and Chaoshan Han population was the smallest (?0.0030), while that between Guangdong and Northeast Han Chinese was the largest (0.0195). The phylogenetic tree was similar to the results of clustering analysis. Multiplex detection of the 22 Y-STR loci revealed a highly polymorphic genetic distribution, which would be very powerful for establishing a Y-STR database, for population genetics and forensic practice.
【Fund】: 广东省自然科学基金(编号:D6301091)资助~~
【CateGory Index】: Q987
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