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《Hereditas》 2008-09
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HLA-DM polymorphisms in Guizhou Han individuals

JIANG Hong-Mei, WANG Yong-Xia, WANG Yong Department of Clinical Microbiology and Immunology, Guiyang Medical College, Guiyang 550004, China  
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine genetic polymorphisms at HLA-DMA/DMB loci in 125 healthy unrelated Han individuals from Guizhou Province. We found that the frequencies of DMA*0101, DMA*0102, and DMA*0103 alleles were 0.720, 0.242, and 0.036, respectively. The fre-quencies of DMB*0101, DMB*0102, DMB*0103, and DMB*0104 alleles were 0.620, 0.156, 0.188, and 0.036, respec-tively. Common genotypes for DMA were DMA*0101/0101 and 0101/0102. Common genotypes for DMB were DMB*0101/0101, 0101/0102, and 0101/0103. These results showed that the genetic polymorphism of HLA-DM gene in Han individuals from Guizhou Province is distinct from other regions.
【Fund】: 贵州省高层次人才科研条件特助经费(编号:030516)资助~~
【CateGory Index】: Q987
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