Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Hereditas》 2008-09
Add to Favorite Get Latest Update

The relationship between the polymorphism of MUC1 and suscepti-bility to gastric cancer in Liaoning region

XU Qian, SUN Li-Ping, GONG Yue-Hua, XU Ying, DONG Nan-Nan, YUAN Yuan Cancer Control Laboratory of Cancer Institute and General Surgery Institute, the First Affiliated Hospital of China Medical University, Shenyang 110001, China  
Analyzed the relationship between 568 site A/G polymorphism in mucin 1(MUC1) gene in a population from Liaoning Province and susceptibility to gastric cancer. Sequence specific primers-polymerase chain reaction(PCR-SSPs) were performed to analyze the genotype of the A/G polymorphism in its 568 site of exon 2 for 138 gastric cancer cases and 131 normal ones tested, and ELISA was performed to test IgG antibody of H. pylori. We found that the distribution fre-quency of AA, AG, GG three genotypes were 73.3%, 22.1%, 4.6%, respectively. The frequency of AA genotype was statis-tically higher in the gastric cancer (GC) group compared to the control group(P=0.03), moreover, individuals with the MUC1 AA genotype increased 1.92 fold risk for gastric cancer. And compared with subjects carrying both AG+GG geno-type and H. pylori-IgG negative, there was an obviously increased risk of developing gastric cancer for those who carried both AA genotype and H. pylori-IgG negative, both AG+GG genotype and H. pylori-IgG positive, and both AG+GG geno-type and H. pylori-IgG negative, but there were no significantly differences between the every two of the latter three. Our results indicated that there was a relationship between MUC1 A/G polymorphism and susceptibility to gastric cancer. Andthere were probably no statistically interaction between the 568 site A/G polymorphism in MUC1 and H. pylori infection in the occurrence and development process of gastric cancer.
【Fund】: 国家自然科学基金(编号:30572131)资助~~
【CateGory Index】: R735.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 3 Hits
1 LI Jie1,GUO Wei-dong2,ZHANG Hui-jie2(1.Department of Postgraduate 2008,Inner Mongolia Medical College,Huhhot 010059 China;2.Department of Oncology,The Third Affiliated Hospital of Inner Mongolia Medical College,Baotou 014010 China);The Research Progress in the Relationship between Mucins and Gastrointestinal Cancer[J];内蒙古医学杂志;2011-01
2 JIANG Ying-Mei1,LIU Chun2,WU Liu-Cheng1,SHAO Yi-Xiang1,2 1.Laboratory Animals Centre,Nantong University,Nantong 226001,China;2.Institute of Comparative Medicine,Nantong University,Nantong 226001,China;Fine mapping of mutant gene related corneal opacity mouse with SNPs[J];遗传;2010-05
3 YANG Yong-qiang,WANG Wei-jie,XU Chang-bo(College of Chemical Engineering and Biotechnology,Hebei Polytechnic University,Tangshan 063009,China);Research Progress of Single Nucleotide Polymorphism[J];化学与生物工程;2009-08
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 LI Zhen-ping1,LI Xiao-yan2(1.Baoshan College of Traditional Chinese Medicine,Baoshan 678000,Yunnan Province,China;2.The First Affiliated Hospital of Kunming Medical College);CDX2 and MUC2 detected and increased reflux esophagitis and Brarrett esophagus diagnosis Graduate[J];医学信息(内·外科版);2009-09
2 Zhang Xiuru,Li Fang,Hou Fang,et al.Department of pathology,Aerospace Clinical Medical College of Peking University,Beijing 100049;Expression and significance of Muc-1,Muc-2,Muc5AC,Muc-6 in hyperplastic polyp,globoid dysplasia,gastric signet ring cell carcinoma[J];中国现代医药杂志;2009-04
3 XU Qian, SUN Li-Ping, GONG Yue-Hua, XU Ying, DONG Nan-Nan, YUAN Yuan Cancer Control Laboratory of Cancer Institute and General Surgery Institute, the First Affiliated Hospital of China Medical University, Shenyang 110001, China;The relationship between the polymorphism of MUC1 and suscepti-bility to gastric cancer in Liaoning region[J];遗传;2008-09
4 LIU Fu-ping1,2,BAI Jun-jie1 (1. Pearl River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Key Laboratory of Tropical and Subtropical Fish Breeding & Cultivation,Chinese Academy of Fishery Sciences,Guangzhou 510380,China;2. College of Aqua-life Science and Technology,Shanghai Ocean University,Shanghai 200090,China);Single nucleotide polymorphisms and its application in genetic breeding of aquatic animals[J];中国水产科学;2008-04
5 GUO Xiao-Ling,CHEN Zhe,ZHAO Xiao-Feng,XU Ning-Ying College of Animal Science,Zhejiang University,Hangzhou 310029,China;Effect of SNP in the exon 8 of SIM1 gene on backfat thickness in pigs[J];遗传;2008-06
6 WANG Yan1,ZHANG Jun2,HUANG Qing-Yang1 1. College of Life Sciences,Central China Normal University,Wuhan 430079,China; 2. Yiling Hospital of Yichang City,Hubei Province,Yichang 443100,China;Association studies of the APM1 SNP T45G with type 2 diabetes in Han population of Hubei Province[J];遗传;2008-06
7 Chen Dong Wu Dengjun(Animal Department of Sichuan Agriculture university,Ya'an 625014);Approaches for SNP Genotyping[J];生物技术通报;2008-02
8 FAN Zhong-Peng1, ZHU Wang-Sheng1, ZHANG Chao1, ZHOU Yu-Xun1, LI Kai1, LIANG Yin-Ming1, XING Zheng-Hong2, CHEN Guo-Qiang2, BAI Xiong2, XIAO Jun-Hua1,2 1. Institute of Biology Science & Technology, Donghua University, Shanghai 201620, China; 2. Institute of Experimental Animals-Fudan University-Donghua University United Laboratory of Bio-Diversity of Model Animals, Shang-hai 201200, China;SNP discovery by F-CSGE in the coding region of mitochondrial DNA in wild house mice from Shanghai suburb[J];遗传;2008-04
9 Yu Xiuwen,Cheng Hui,Wang Jingfen.Department of Pathology,Qiqihaer Medical College,Heilongjiang 161042,China;Associated Expression Mucin MUC1、MUC2 and Matrix Metalloproteinase (MMP-3) in Colorectal Carcinoma and Their Clinical Significance.[J];医学研究杂志;2008-01
10 TAND Di,WANG Zhi-min(School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai 201101,China);Advances in Methods for SNP Detection[J];上海交通大学学报(农业科学版);2007-04
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Song Hongyan;Li Yao;Lu Zeyan;Wu Liucheng;Shao Yixiang;Laboratory Animal Center of Nantong University;;Change of serum response factor expression in eyelid of different embryo development stages of B6-Co mice[J];中华实验眼科杂志;2015-08
2 CHEN Xiao-long;ZHANG Shu-ying;XU An-gao;Graduate College of Guangdong Medical College;Huizhou Medicine Institute;;Research Progress in Relation between IL-23 / IL-17 Axis Signaling Pathway and Colorectal Carcinoma[J];医学综述;2015-11
3 ZHENG Liang-feng;WANG Sheng-jie;WU Liu-cheng;LIU Chun;LI Yao;SHAO Yi-xiang;Haian Affiliated Hospital,Nantong University;Institute of Comparative Medicine,Nantong University;;Expression of MEKK1 during the development of the B6-Co mouse embryo[J];黑龙江畜牧兽医;2015-01
4 MIAO Jin;LI Yao;LIU Chun;SONG Hong-Yan;SHAO Yi-Xiang;Laboratory Animal Center,Comparative Medicine Institute of Nantong University;;Expression of TGFα/EGFR signal pathway-associated protein in B6-Co mice embryonic eyelids[J];眼科新进展;2015-01
5 WANG Lili;LIN Yulin;CHEN Xiaochen;LIAO Baosheng;WANG Xiaoyue;HAN Jianping;National Engineering Laboratory for Breeding of Endangered Medicinal materials,Institute of Medicinal Plant Development,Chinese Academy of Medicinal Science &Peking Union Medicinal College;;Molecular Authentication of the Oriental Medicine Acorus calamus Based on SNP Markers[J];中国现代中药;2014-11
6 Song Bingke;Ni Pingya;Zhang Ying;Xu Xiaoyu;Tu Zheng;Yang Xueying;Pei Li;Chinese People's Public Security University;Institute of Forensic Science, Ministry of Public Security;;Advances in Cannabic New Genetic Markers and Its Application[J];分子植物育种;2014-03
7 FAN Jia-jia;LIU Xiao-xian;BAI Jun-jie;YU Ling-yun;Pearl River Fisheries Research Institute,CAFS/Key Laboratory of Tropical & Subtropical Fishery Resource Application & Cultivation,Ministry of Agriculture;;Detection of SNP incitrate synthase gene and association analysis with growth traits in grass carp(Ctenopharyngodon idellus)[J];华中农业大学学报;2014-03
8 Wu Liucheng;Zhang Liuliu;Li Yao;Wang Shengjie;Ji Ren;Ni Yaowei;Shao Yixiang;Institute of Comparative Medicine,Nantong University;Medical School,Nantong University;;The study on clone sequencing and expression of Fgf10 in corneal opacity mouse[J];重庆医学;2013-36
9 YAO Jing1,2, GUO Xiao-Jun2, WANG Su2, WANG Yu-Chao2, LUO Chen2,*, ZHANG Fan2, LI Shao-Qin1,* (1. Hubei Insect Resource Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; 2. Institute of Plant and Environmental Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China);Discrimination of cryptic species MEAM1 and MED of Bemisia tabaci (Hemiptera: Aleyrodidae) by using TaqMan allele-selective PCR[J];昆虫学报;2013-01
10 Guan Cheng-qi1,Jiang Kang-lun1,Wu Liu-cheng2,Ling Xue-ping2,Shao Yi-xiang2 1Medical College of Nantong University,Nantong 226001,Jiangsu Province,China;2Institute of Comparative Medicine,Nantong University,Nantong 226001,Jiangsu Province,China;Two-dimensional gel electrophoresis analysis of opaque corneal tissue protein in B6-Co mutant mice[J];中国组织工程研究;2012-46
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved