Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Hereditas》 2008-09
Add to Favorite Get Latest Update

The relationship between the polymorphism of MUC1 and suscepti-bility to gastric cancer in Liaoning region

XU Qian, SUN Li-Ping, GONG Yue-Hua, XU Ying, DONG Nan-Nan, YUAN Yuan Cancer Control Laboratory of Cancer Institute and General Surgery Institute, the First Affiliated Hospital of China Medical University, Shenyang 110001, China  
Analyzed the relationship between 568 site A/G polymorphism in mucin 1(MUC1) gene in a population from Liaoning Province and susceptibility to gastric cancer. Sequence specific primers-polymerase chain reaction(PCR-SSPs) were performed to analyze the genotype of the A/G polymorphism in its 568 site of exon 2 for 138 gastric cancer cases and 131 normal ones tested, and ELISA was performed to test IgG antibody of H. pylori. We found that the distribution fre-quency of AA, AG, GG three genotypes were 73.3%, 22.1%, 4.6%, respectively. The frequency of AA genotype was statis-tically higher in the gastric cancer (GC) group compared to the control group(P=0.03), moreover, individuals with the MUC1 AA genotype increased 1.92 fold risk for gastric cancer. And compared with subjects carrying both AG+GG geno-type and H. pylori-IgG negative, there was an obviously increased risk of developing gastric cancer for those who carried both AA genotype and H. pylori-IgG negative, both AG+GG genotype and H. pylori-IgG positive, and both AG+GG geno-type and H. pylori-IgG negative, but there were no significantly differences between the every two of the latter three. Our results indicated that there was a relationship between MUC1 A/G polymorphism and susceptibility to gastric cancer. Andthere were probably no statistically interaction between the 568 site A/G polymorphism in MUC1 and H. pylori infection in the occurrence and development process of gastric cancer.
【Fund】: 国家自然科学基金(编号:30572131)资助~~
【CateGory Index】: R735.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 3 Hits
1 YANG Yong-qiang,WANG Wei-jie,XU Chang-bo(College of Chemical Engineering and Biotechnology,Hebei Polytechnic University,Tangshan 063009,China);Research Progress of Single Nucleotide Polymorphism[J];Chemistry & Bioengineering;2009-08
2 LI Jie1,GUO Wei-dong2,ZHANG Hui-jie2(1.Department of Postgraduate 2008,Inner Mongolia Medical College,Huhhot 010059 China;2.Department of Oncology,The Third Affiliated Hospital of Inner Mongolia Medical College,Baotou 014010 China);The Research Progress in the Relationship between Mucins and Gastrointestinal Cancer[J];Inner Mongolia Medical Journal;2011-01
3 JIANG Ying-Mei1,LIU Chun2,WU Liu-Cheng1,SHAO Yi-Xiang1,2 1.Laboratory Animals Centre,Nantong University,Nantong 226001,China;2.Institute of Comparative Medicine,Nantong University,Nantong 226001,China;Fine mapping of mutant gene related corneal opacity mouse with SNPs[J];Hereditas;2010-05
Chinese Journal Full-text Database 10 Hits
1 HUANG Wen bin1*, SHI Liang hui2, ZHU Xiao qun1, XU Guo xiang3, QI Qiong11. Department of Pathology, Wannan Medical College, Wuhu 241001,P. R. China2. Department of General Surgery,The Affiliated Yijishan Hospital, Wannan Medical College, Wuhu;Expression of Mucin MUC1 and MUC2 in Colorectal Carcinoma and Their Clinical Significance[J];Chinese Journal of Cancer;2002-11
2 WANG Yi-Min1,2, GUO Wei1, ZHANG Xiu-Feng1, LI Yan1, WANG Na1, GE Hui1, WEI Li-Zhen3, WEN Deng-Gui3, ZHANG Jian-Hui1 1. Laboratory of Molecular Biology,Hebei Provincial Cancer Institute /TheFourth Affiliated Hospital,Hebei Medical University,Shijiazhuang, Hebei, 050011,P. R. China2. Department of General Surgery,The First Hospital ofQinhuangdao City,Qinhuangdao, Hebei, 066000,P. R. China3. Laboratory of Epidemiology,Hebei Provincial Cancer Institute /TheFourth Affiliated Hospital,Hebei Medical University,Shijiazhuang, Hebei, 050011,P. R. China;Correlations between Serine Hydroxymethyltransferase1 C1420T Polymorphisms and Susceptibilities to Esophageal Squamous Cell Carcinoma and Gastric Cardiac Adenocarcinoma[J];Chinese Journal of Cancer;2006-03
3 ZHOU Rong-Miao, LI Yan, WANG Na, ZHANG Xiao-Juan, DONG Xiu-Juan, GUO Wei Laboratory of Molecular Biology, Hebei Provincial Cancer Institute, Shijiazhuang, Hebei, 050011, P. R. China;Correlation of XPC Ala499Val and Lys939Gln Polymorphisms to Risks of Esophageal Squamous Cell Carcinoma and Gastric Cardiac Adenocarcinoma[J];Chinese Journal of Cancer;2006-09
4 Liu Ju Xu Binghe# Cancer Institute & Hospital,CAMS & PUMC,Beijing 100021,China;Correlation of single nucleotide polymorphism and prognosis of breast cancer[J];Oncology Progress;2007-03
5 Wang Rongquan; Fang Dianchun; Liu Weiwen; Jin Huayuan; Lu Rong (Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing,400038);Detection of the expression of MUCI gene in normal human glandular epithelial cells with BC2 monoclonal antibody[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;1999-06
6 XIANG Song-tao1, ZHOU Si-wei2, GUAN Wei2, HU Zhi-quan2, ZHUANG Qian-yuan2, YE Zhang-qun21Department of Urological Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine/Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, China; 2Department of Urological Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;Value of quantitative examination of urine MUC1 in bladder transitional cell carcinoma[J];Journal of First Military Medical University;2005-08
7 Yi Junling.Chinese People's Public Security University,Beijing 100038;Single Nucleotide Polymorphisms And Detection Approaches[J];Evidence Science;2008-06
8 YU Jian1,2,PANG Hao1,WANG Bao-jie1 (1. School of Forensic Medicine,China Medical University,Shenyang 110001,China; 2. Traffic Police Department,Shenyang Public Security Bureau,Shenyang 110003,China);The Association of Tyrosine Hydroxylase Gene Polymorphism with Mental Disorder[J];Journal of Forensic Medicine;2008-05
9 ZHANG Qinxian, DU Peng, LE Xiaoping, DING Yi, WU Jinglan Molecular Cell Biology Research Center, Henan Medical University;Henan Key Laboratory of Molecular Medicine, Zhengzhou 450052;Expression of hMSH2 mRNA in human gastric cancer tissues[J];Journa of Henan Medical University;2001-04
10 ZHANG Li yan (Department of Psychology,South China Normal University,Guangdong Guangzhou 510631,China);Antagonism and Integration of Two Traditions in Personality Research[J];;2003-01
【Secondary References】
Chinese Journal Full-text Database 9 Hits
1 WU Liu-Cheng① SHAO Yi-Xiang①② ① Laboratory Animals Centre,Nantong University,Nantong 226001; ② Institute of Comparative Medicine,Nantong University,Nantong 226001,China;Map3k1 Regulation of Mouse Eyelid Closure[J];Chinese Journal of Zoology;2011-03
2 WU Liu-cheng1,LIU Chun2,JIANG Ying-mei1,WANG Sheng-cun,SHAO Yi-xiang1,2(1.Laboratory Animals Centre,Nantong University,Nantong,Jiangsu,226001,China;2.Institute of Comparative Medicine,Nantong University,Nantong,Jiangsu,226001,China);Cloning and Sequence Analysis of Mutant Candidate Gene of Map3k1 in Cornea Opacity Mouse[J];Progress in Veterinary Medicine;2011-04
3 CHEN Bing①② LI Ke ② CHEN De-Yang② MI Ting② XUE Zheng-Feng①② ①Comparative Medicine Center,Yangzhou University,Yangzhou 225009; ②College of Veterinary Medicine,Yangzhou University,Yangzhou 225009,China;Generation of Polydactylous Mice Using ENU Mutagenesis and Identification of the Mutant Gene[J];Chinese Journal of Zoology;2012-05
4 YAO Jing1,2, GUO Xiao-Jun2, WANG Su2, WANG Yu-Chao2, LUO Chen2,*, ZHANG Fan2, LI Shao-Qin1,* (1. Hubei Insect Resource Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; 2. Institute of Plant and Environmental Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China);Discrimination of cryptic species MEAM1 and MED of Bemisia tabaci (Hemiptera: Aleyrodidae) by using TaqMan allele-selective PCR[J];Acta Entomologica Sinica;2013-01
5 CAO Ting-ting1,2,BAI Jun-jie1,2,YU Ling-yun1,FAN Jia-jia1(1.Key Lab of Tropical & Subtropical Fish Breeding & Cultivation of Chinese Academy of Fishery Sciences,Pearl River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Guangzhou 510380,China; 2.College of Fisheries and Life Sciences,Shanghai Ocean University,Shanghai 201306,China);Polymorohisms of SNPs in ALDO B gene and association analysis with growth traits in grass carp(Ctenopharyngodon idellus)[J];Journal of Fisheries of China;2012-04
6 Tang Liqun1,2,Xiao Cenglin1,Wang Weiping2,3(1Hunan Agricultural University,Changsha 410128;2Key Laboratory of Hybrid Rice,Changsha 410125;3Hunan Hybrid Rice Research Center,Changsha 410125);Research and Application Progress of SNP Markers[J];Chinese Agricultural Science Bulletin;2012-12
7 SHEN Xing-jiao,YUE Bing-fei(National Institutes For Food And Drug Control,Beijing 100050);Application of the Technology of Molecular Markers on the Analysis of Genetic Diversity of Rabbits[J];Chinese Journal of Comparative Medicine;2012-09
8 TIAN Yi-ke,WANG Cai-hong * ,BAI Mu-dan,YIN Hao,and LI Jie-fa (College of Landscape and Horticulture,Qingdao Agricultural University,Qingdao,Shandong 266109,China);Development of Functional SNP Markers Anchored PpKO Gene in Pear[J];Acta Horticulturae Sinica;2012-10
9 Guan Cheng-qi1,Jiang Kang-lun1,Wu Liu-cheng2,Ling Xue-ping2,Shao Yi-xiang2 1Medical College of Nantong University,Nantong 226001,Jiangsu Province,China;2Institute of Comparative Medicine,Nantong University,Nantong 226001,Jiangsu Province,China;Two-dimensional gel electrophoresis analysis of opaque corneal tissue protein in B6-Co mutant mice[J];Chinese Journal of Tissue Engineering Research;2012-46
China Proceedings of conference Full-text Database 3 Hits
1 WU Liu-Cheng~1,LIU Chun~2,JIANG Ying-Mei~1,WANG sheng-Cun,SHAO Yi-Xiang~(1,2) (1.Laboratory Animals Centre,Nantong University,Nantong 226001,China;2.Institute of Comparative Medicine,Nantong University,Nantong 226001,China );Mutant candidate gene cloning and sequence analysis of Map3kl in Cornea Opacity mouse[A];[C];2010
2 WU liu-cheng~(1,2),LIU chun~(1,2),LU ze-yan~1,ZHENG liang-feng~1,LI yao~1,SHAO yi-xiang~(1,2) (1 Laboratory Animals Centre,Nantong University,Nantong 226001,China;2 Institute of Comparative Medicine,Nantong University,Nantong 226001,China);Study on the formation mechanism of eyelids development defect in B6-Co mouse[A];[C];2012
3 ZHENG liang-feng~1,WU liu-cheng~(1,2),LIU chun~(1,2),LI yao~1,WANG sheng-jie~1,SHAO yi-xiang~(1,2) (1 Laboratory Animals Centre,Nantong University,Nantong 226001,China;2 Institute of Comparative Medicine,Nantong University,Nantong 226001,China);The expression of MEKK1 in the development of B6-Co fetus[A];[C];2012
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved