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《Hereditas》 2008-09
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The relationship between the polymorphism of MUC1 and suscepti-bility to gastric cancer in Liaoning region

XU Qian, SUN Li-Ping, GONG Yue-Hua, XU Ying, DONG Nan-Nan, YUAN Yuan Cancer Control Laboratory of Cancer Institute and General Surgery Institute, the First Affiliated Hospital of China Medical University, Shenyang 110001, China  
Analyzed the relationship between 568 site A/G polymorphism in mucin 1(MUC1) gene in a population from Liaoning Province and susceptibility to gastric cancer. Sequence specific primers-polymerase chain reaction(PCR-SSPs) were performed to analyze the genotype of the A/G polymorphism in its 568 site of exon 2 for 138 gastric cancer cases and 131 normal ones tested, and ELISA was performed to test IgG antibody of H. pylori. We found that the distribution fre-quency of AA, AG, GG three genotypes were 73.3%, 22.1%, 4.6%, respectively. The frequency of AA genotype was statis-tically higher in the gastric cancer (GC) group compared to the control group(P=0.03), moreover, individuals with the MUC1 AA genotype increased 1.92 fold risk for gastric cancer. And compared with subjects carrying both AG+GG geno-type and H. pylori-IgG negative, there was an obviously increased risk of developing gastric cancer for those who carried both AA genotype and H. pylori-IgG negative, both AG+GG genotype and H. pylori-IgG positive, and both AG+GG geno-type and H. pylori-IgG negative, but there were no significantly differences between the every two of the latter three. Our results indicated that there was a relationship between MUC1 A/G polymorphism and susceptibility to gastric cancer. Andthere were probably no statistically interaction between the 568 site A/G polymorphism in MUC1 and H. pylori infection in the occurrence and development process of gastric cancer.
【Fund】: 国家自然科学基金(编号:30572131)资助~~
【CateGory Index】: R735.2
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