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《Hereditas》 2018-10
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Avermectins, intelligently made in China

Ying Wen;Lixin Zhang;State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University;State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology;  
Avermectins, are pesticides of fermentation products with high efficacy and low toxicity and play important roles in food and agricultural product safety, animal and human health. Ivermectins, the derivatives of avermectins, are used to treat Onchocerciasis, also known as River Blindness. Thanks to these discoveries, more than 200 million Africans are lucky to be exempted from blindness. Great efforts have been made on better understanding of the microbial production system of avermectins through genetic engineering in China. Starting from scratch, Chinese avermectin industry has experienced a comprehensive technological innovation with significantly improved yield, titer and productivity of avermectins, and became the exclusive supplier for the global market. The success of avermectin industry innovation in China not only shed lights on the intelligent yield improvement of other microbial natural product drugs, but also gained wide international recognition. We provide here an overview of the discovery and development of basic and applied research of avermectins, especially historical evolution of avermectins made in China, which will benefit industrial development of microbial drugs in China.
【Fund】: 国家自然科学基金项目(编号:31430002 31320103911 31500690 31670052 31600017);; 国家重点研发项目(编号:2017YFD0201207);; 华东理工大学交叉团队项目(编号:22221818014);; 山东省重点研发项目(编号:ZR2017ZB0206);; 泰山学者计划项目资助~~
【CateGory Index】: TQ453
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