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《Hereditas》 2018-10
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Gene editing technology and its research progress in China

Yiou Chen;Ying Bao;Huazheng Ma;Zongyi Yi;Zhuo Zhou;Wensheng Wei;School of Life Science, Peking University;PKU-Tsinghua Center for Life Sciences;Academy for Advanced Interdisciplinary Studies, Peking University;Biomedical Pioneering Innovation Center, Peking University;Beijing Advanced Innovation Center of Genomics;Peking University Genome Editing Research Center;  
Gene editing is a technology for precision modification of genome sequences or expressing transcripts. Early versions of such techniques include homing endonuclease, zinc finger endonuclease and transcription-like activator effectors. The CRISPR/Cas9 system has recently emerged as a powerful and versatile gene editing tool for a broad spectrum of applications. In this review, we discuss the recent development and applications of gene editing technology, and particularly focus on the progress in China, with the emphasis on mechanistic studies, development of new and extended technologies, the applications in animals, plants and the therapeutics.
【Fund】: 国家自然科学基金项目(编号:31430025)资助~~
【CateGory Index】: Q78
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