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《Chinese Journal of Sports Medicine》 1992-02
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EFFECT OF SWIM TRAINING ON MYOCARDIAL α_1-ADRENOCEPTOR AND ITS SUBTYPES IN RATS

Hou Xiangyu, et al Beijing Medical University  
Changes of a_1-adrenoceptor and its subtypes in myocardium were studied by radioligand binding assay inrats which received swim training for 8 weeks. The ~(125)I-BE~(2254) scatchard analyses showed that Bmax inthe training group (n = 5) was significantly increased from 43.3±5.6 fmol/mg in the control group (n = 5)to 75.0 ± 8.2 fmol/mg (p0.02), while K_D was not changed. Two-site analysis of inhibition of specific~(125)I-BE binding by WB4101 showed there existed high affinity site (a_1 subtype) and low affinity site (a_(1b)subtype). The a_(1a) subtype accounted for 28.5% of the total a_1-adrenoceptor in the control group, but itincreased to 39.5% in the training group. The results indicate that a_1-adrenoceptor, especially a_(1a) subtype,increased after swim training, which might link to myocardial hypertrophy in physical exercise.
【Fund】: 国家自然科学基金
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