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《CHINESE JOURANAL OF SPORTS MEDICINE》 2000-01
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Detection of Recombinant Human Erythropoietin Misuse by Immunoassay

FangZilong ,YangShumin ,WangXiaobing ,etal NationalResearchInstituteofSportsMedicine,Beijing 10 0 0 2 9,China  
Sixhealthyyoungmalevolunteersweresubcutaneouslyadministeredbyrecombinanthumanerythropoietin (rhEPO)witha dosageof3 0IU/kgbodyweight,threetimesaweekforfourweeks Fourvolunteersascontrolswereadministeredbyequalplacebo Somebiochemicalparameterswereobservedbyenzyme -linkedimmunosorbentassay (ELISA)inthisstudy EPOandtransferrinsol ublereceptor (TfR)concentrationsinserumwereelevatedbytheadministrationofrhEPO TfRconcentrationmaintainedhigherlevel aftertheadministrationofrhEPOwithinoneweek Totaloffibrinogendegradationproductsandfibrindegradationproducts (TDP) concentrationsinplasmachangedirregularly TheresultssuggestedthatserumEPOandTfRconcentrationmightbethevalidatepa rametersonthedetectionofrhEPOmisuse
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