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《Chinese Journal of Sports Medicine》 2004-01
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The Influences of Immune Suspression by Oral Administration of Type Ⅱ Collagen on Rat Rheumatic Osteoarthritis and Traumatic Osteoarthritis

Sun Jie and Yu Changlong (correspondent author) Institute of Sports Medicine, Peking University,Beijing 100083, China  
Purpose: To study the influences of immune suspression by oral administration of type Ⅱ collagen on the pathogenesis of collagen induced arthritis(CIA) and traumatic oseoarthritis(OA) in rats; Methods: Rat knee traumatic osteoarthritis model made by excision of medial collateral ligament and medial meniscetomy and CIA model were applied for the observation of the changes on hisological and histochemical staining and the inhibition of T cells after oral administration of type Ⅱ collagen. Results: In OA, although the T cells were suspressed by oral administration of type Ⅱ collagen, however, the the pathogenesis was not hindered comparing with RA. It indicated that for OA, machanical factor is more important than the immunological factor, oral administration of type Ⅱ collagen has little effect on decreasing the speed of development of OA. It is not adequate to take the remedy of oral administation of type Ⅱ collagen for the treatment of OA.
【CateGory Index】: R593.22;R684.3
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