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《Chinese Journal of Sports Medicine》 2004-01
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Effects of Exogenous NO Precursor L-Arg on Fatigue in Rat after Endurance Training

Zhang Li, Feng Lianshi and Zong Pifang China Institute of Sports Science, Beijing 100061,China  
Objective:The present study aimed at investigating the effects of L-arginine,a nitric oxide (NO) precursor,on NO produced from tissues and fatigue in endurance treadmill trained rats.Methods:30 SD rats were randomly divided into 3 groups:sedentary group,exercise control group and exercise L-Arg group. The rats in both exercise groups were given 4 weeks of endurance training on treadmill at speed of 34m/min,60m/day,6 days/week,then followed an exhausted running.At the meantime,the rats in exercise L-Arg group were administed L-Arg 40mg/kg body weight by lavage every day.The NO and nitric oxide synthase(NOS)in serum,vastus lateralis,myocardium and liver,and some fatigue indexes,such as creatine kinase(CK),blood urea(BUrea),alanine aminotransferase(ALT),lactate dehydrogenase(LDH)in serum were determined immediately after the exhausted running.Results:(1)The NOS in serum,myocardium and liver in both exercise groups increased significantly,compared with sedentary group,but no difference was observed between two exercise groups,except for in myocardium.(2)The serum CK,BUrea,ALT and LDH in Exercise L-Arg Group were higher than those in exercise control proup,but no statistical significance.Conclusion:It needed to study further that supplementation of L-Arg could promote the production of NO in many tissues and increased the tissue damage induced by free radical during endurance training.
【Fund】: 国家自然科学基金资助项目 项目批准号 :30 1712 0 4
【CateGory Index】: R87
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