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《Chinese Journal of Sports Medicine》 2004-01
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Quantification of 11-Nor-9-carboxy-delta 9-THC in Human Urine with GC/MS/MS

Wu Yun and Wu Moutian National Research Institute of Sports Medicine, China Doping Control Center, Beijing, 100029  
Purpose: To quantify the concentration of 11-Nor-9-carboxy-delta 9-THC in human urine with GC/MS/MS.11-Nor-9-carboxy-delta 9-THC is the major active metabolite in human urine after cannabis abuse, and thus it can be the evidence for cannabis abuse. GC/MS/MS technique provides very sensitive and reliable results. Methodology: Before the GC/MS/MS analysis, the urine sample should be hydrolyzed with alkalinity (KOH methanol solution) to make 11-Nor-9-carboxy-delta 9-THC in free form, then the pH value is adjusted with HCl and glacial acetic acid to about 3.5, the solution is extracted with n-heptane tree times, the organic phase is evaporated under nitrogen. The residue is derivatization, 1μl of the derivatized solution is injected into GC/MS/MS. Results: Cover IOC cut level.
【CateGory Index】: R87
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