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《Chinese Journal of Sports Medicine》 2009-01
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Association between KCNA7 Gene T418M Polymorphism and the Response of Body Composition to the Aerobic Training

Bao Dapeng1,Hu Yang2,Wu Jian3,Xi Yi4,Wen Li5,Zhang Haixia61 Graduate School,Beijing Sport University,Beijing,China 1000842 Sport Science Research Center,Beijing Sport University,Beijing,China 1000843 Capital Institute of Physical Education,Beijing,China 1000884 PE Department,Shenzhen University,Shenzhen,China 5180605 Sport Science Department,Tianjin Institute of Physical Education,Tianjin,China 3003816 Beijing Genomics Institute,Chinese Academy of Sciences,Beijing,China 101300  
Purpose To explore the relation of the characteristics of polymorphisms in the KCNA7 gene phenotypes to the response of body component to the aerobic training. Methods One hundred and two healthy men of Han nationality in northern China were recruited to undergo aerobic training program for 18 weeks.Body composition was measured before and after the training program.The genotype was analyzed by PCR-RFLP.One way ANOVA was used to analyze differences in the changes of variables between genotypes. Results There were significant differences between gene polymorphism and BMI before training,whereas these changes were no significant after training.On the contrary,no associations were detected between the gene polymorphism and LBW before training,but significant difference in the changes were shown after training. Conclusion The present study demonstrated that KCNA7 gene T418M polymorphism can be used as a sensitive indicator of LBW in response to endurance training in molecular biology.
【Fund】: 科技部奥运攻关课题(2003BA904B04)
【CateGory Index】: R87
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