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《Chinese Journal of Sports Medicine》 2009-01
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Effects of Progressive Strenuous Exercise on the PI3K/Akt Signaling Pathway in Skeletal Muscle of Rats

Chen Caizhen,Lu Jian,Ding Shuzhe,Li Haipeng,Qi Zhengtang College of Physical Education & Health,East China Normal University,Shanghai,China 200241  
Objective To investigate the effects of exercise on the signaling pathway of PI3K/Akt and the protein synthesis after progressive strenuous exercise. Methods Male SD rats were randomly divided into two groups: control group(n=6) and progressive strenuous exercise group(n=6).The level of mRNA and protein expression of Akt,PTEN and PI3K were detected by the methods of real-time PCR and Western blotting in soleus and gastrocnemius. Results(1)The level of Akt mRNA significantly decreased in both of the muscles after progressive strenuous exercise,and the expression of Akt in gastrocnemius significantly increased;(2)No effect of progressive strenuous exercise on PTEN mRNA and it's expression was seen;(3)The expression of PI3K in soleus significantly increased after progressive strenuous exercise,but no effect of progressive strenuous exercise on the relative expression of PI3K mRNA in both of the muscles was seen. Conclusion The decrease in Akt could be occurred independently without change in PI3K,and progressive strenuous exercise could possibly switch on the inactive pathway.It was also implied that there might be other activation pathways of Akt besides the PI3K.
【Fund】: 华东师范大学梯队建设(211配套)项目(521B0342)
【CateGory Index】: R87
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【References】
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【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Luo Kai1,Wang Zhi-yuan1,Zhang Di-di1,Liu Chen-tao2(1.College of Physical Education,Shanxi Normal University,Xian 710062,Shanxi China;2.P E Department,Northwest University,Xian 710069,Shanxi China);Effect of Resistance Training On PI3K And Akt Gene Expression In Quadriceps Femoris Muscles Of Rats[J];福建体育科技;2013-04
2 Chen Yan1,Han Sheng2,Liu Wenchao1 1Department of Oncology,Xijing Hospital,The Fourth Military Medical University,Shaanxi Xi'an 710032,China;2Department of Information Center,School of Stomatology,The Fourth Military Medical University,Shaanxi Xi'an 710032,China;The molecular mechanism of PI3K/AKT/mTOR signal pathway regulating the expression of fatty acid synthase in breast cancer[J];现代肿瘤医学;2013-01
3 XU Guo-qin,CHEN Xiao-bin,MENG Yan,WANG Ren-gang Exercise Biochemistry Laboratory,Guangzhou Sport University,Guangzhou,510500,Guangdong,China;Effect of different intensity exercise on SREBP and liver steatosis in diabetes rats[J];山东体育学院学报;2012-06
4 ZHANG Ya-li1,ZHU Hong-min1,WANG Jian-qing2,CHEN Tao1,TAO Jian-shu1(1 Department of Clinical Laboratory Medicine,Guiyang Medical College,Guiyang 550004,China; 2 Department of Clinical biochemistry,Affiliated hospital to Guiyang Medical College,Guiyang 550004,China);The Effects of Rapamycin on Expression of Hypoxia Signal Molecules in Human Acute Myeloid Leukemic Cell Line HL-60 Under Hypoxia[J];现代生物医学进展;2012-28
5 Zhan Minxia,Wu Guanzhong*(Department of Pharmacology,China Pharmaceutical University,Nanjing 210009,China);Fatty Acid Synthase and Disease[J];亚太传统医药;2012-09
6 Wang Jinhao 1,2,Lu Yingli 1,Feng Lianshi 1,Wang Xuebing 3,Zhang Li 1,Xu Jianfang 1 1 China Institute of Sport Science,Beijing,China 100061 2 Shanghai Research Institute of Sport Science,Shanghai,China 200030 3 Guangxi University,Nannin,China 530004;Living High Training High Inhibits the SREBP-1c Expression in Obese Rats Liver[J];中国运动医学杂志;2012-07
7 Shi Jiaojiao1,Mi Mantian2,Wei Na2,Wang Bin2,Yi Long2,Zhang Qianyong2 (1.Department of Trophology,General Hospital of Chengdu Military Region,Chengdu,Sichuan 610083,China;2.Research Center for Nutrition and Food Safety,Third Military Medical University/Chongqing Key Laboratory of Nutrition and Food Safety,Chongqing 400038,China);Effect of fatty acid compositions in different diets on expression of lipid metabolism related genes in rat liver[J];重庆医学;2012-13
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【Secondary References】
Chinese Journal Full-text Database 4 Hits
1 LIU Yang;MIAO Yu-chuan;Department of Pathology, Shanxi University of Traditional Chinese Medicine;;Changes of activity of PI3K/Akt/mTOR signaling pathway in early stage of spinal cord injury of rats and its relationship with recovery of motor function of posterior limbs[J];上海交通大学学报(医学版);2015-06
2 Ma Tie;Zeng Fanxing;Shenyang Sport University;Beijing Sport University;;The Characteristics of Skeletal Muscle Protein Synthesis during Three-week High Volume Training[J];中国运动医学杂志;2015-05
3 TAO Yu-jing;ZHANG Qiang;LIU Jun-yi;School of Physical Education,Northeast Normal University;;Correlation Analysis and Study on the Influences of Vibration Training over Rats' Skeletal Muscle Strength,IGF-1 and Myostatin Expression[J];西安体育学院学报;2014-01
4 HUANG Dan;MENG Yan;WENG Xiquan;LIN Wentao;Foshan University;Guangzhou Sports University;;Effects of Different Hypoxia Training on Skeletal Muscle Satellite Cells Activation Signal Pathway of NO /HGF /c-Met[J];沈阳体育学院学报;2013-05
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