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《Chinese Journal of Sports Medicine》 2010-01
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Effect of Endurance Training on the Cardiac Akt/mTOR Signaling Pathway in Aged Mice

Li Xin 1,2,Ding Shuzhe 1,Lu Jian 11 School of Sports and Health Care,East China Normal University,Shanghai,China 2002412 Institute of Sports and Healthy Education,Mianyang Normal University,Sichuan,China 621000  
Objective To study the effect of endurance training on the cardiac Akt/mTOR signaling pathway in aged mice.Methods Male 2-month-old SAMP8 mice were randomly divided into young control group(YC)(n=12),endurance training group(E)(n=12)and aged control group(AC)(n=12).The group YC was executed at three-month old;and the group AC was executed at six-month old.The group E underwent a 3-month endurance training program(three times per week,40min once a day).After completion of the training programt,he ratio of heart mass to body mass(heart mass/body mass) was measured,cardiac tissue of each group was observed using the HE stain,and the mRNA expressions of Akt,mTOR,p70S6K and eIF-4E in mouse heart of each group were analyzed using the real-time PCR.Results The heart weight and the heart weight/body weight ratio significantly increased in group E comparing with that in group AC(P 0.05)without any pathological change.The mRNA expressions of Akt,mTOR,p70S6K and eIF-4E in group AC decreased more significantly than that in group YC(P 0.05).The expression of targets in group E increased more significantly than that in group AC(P 0.05),howevert,here was no significance difference between group E and group YC.Conclusion Endurance training can elevate the cardiac Akt/mTOR signaling pathway expression,produce exercise-induced cardiac hypertrophy for aged mice.
【CateGory Index】: R87
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【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 LIU Xiang-mei,WU Yu-qiang,TAN-Jun,LIU Wen-fengHunan Normal University,Changsha 410012,China.;Study on Renal Cell Apoptosis and Influence Mechanism of Low Intensity Exhausted Exercise Rat after Endurance Training[J];China Sport Science;2007-05
2 WU Wei1, LI Xin1,2 (1.School of PE and Health Education, Mianyang Normal University, Mianyang 621000, China; 2.School of PE and Health, East China Normal University, Shanghai 200241, China);Influence of Different Style Exercise on Aging Mice Cardiac Apoptosis[J];Journal of Tianjin University of Sport;2009-06
3 Ren Wen-jun Department of Physical Education, Key Laboratory of Biomedical Information Engineering of Education Ministry, School of Life Science and Technology, Xi'an Jiaotong University, Xi′an 710049, Shaanxi Province, China;Changes in the contractile function of gastrocnemius myosin after aerobic exercise[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2007-10
4 LI Xin1,2,LU Jian1,ZHAO Hong-yang1(1.School of Sports and Health Care,East China Normal University,Shanghai 200241,China;2.Institute of Sports and Healthy Education,Mianyang Normal University,Mianyang 621000,China);Effect of Long-term Endurance Exercise on Apoptosis of Cardiac Sacopenia[J];Journal of Xi'an Physical Education University;2009-06
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