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《Chinese Journal of Sports Medicine》 2011-01
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Effects of Exercise-induced Fatigue on the GDNF and GFRα-1 mRNA Expression in Hippocampus of Mice

Wu Chunyan1,Wu Zhichun2,Song Huixiao3 1 Shandong Research Center of Sports Sciences,Ji' nan,China 250022 2 Shandong University of Traditional Chineses Medicine,Ji' nan,China 250355 3 Shandong Hospital of Traditional Chinese Medicine,Ji' nan,China 250011  
Objective To investigate the expressions of glial cell-derived neurotrophic factor(GDNF)and GDNF specific receptor(GFRα-1)mRNA in hippocampus of mice with exercise-induced fatigue.Methods Twenty healthy mice(Kunming species)were randomly divided into control group and experimental group.Mice in experimental group swam with incremental intensity(from 60 minutes to 90 minutes and finally 120 minutes),once a day,6 times per week,for a total of 4 weeks.Body weight(BW),blood urea nitrogen(BUN),creatine kinase(CK)and testosterone(T)were tested after exercise.GDNF and GFRα-1 mRNA expression were observed with RQ-PCR method.Results The level of BW and T in experimental group was significantly lower than that in control group,and the levels of CK,BUN,and the expressions of GDNF and GFRα-1 mRNA in experimental group were significantly higher than that in control group(P 0.05).Conclusion Exercise-induced fatigue increases the level of GDNF and GFRα-1 mRNA expression,suggesting that both GDNF and its receptor GFRα-1 involve in the neurobiological modulation for exercise-induced fatigue.
【Fund】: 山东省自然科学基金项目(ZR2009CQ032)
【CateGory Index】: R87
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