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《Chinese Journal of Sports Medicine》 2018-01
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Effects of Aerobic and Resistance Exercises on Morphology and Activity of Brown Adipose Tissues in Rats

Yang Xingya;Tian Ye;Feng Baoxin;Li Pengfei;Fang Guoliang;Li Liang;Yu Tao;China Institute of Sport Science;Sports Culture Development Center,General Administration of Sport of China;  
Objective To compare the effect of aerobic and resistance exercise on brown adipose tis-sues in rats. Methods Sprague-Dawley rats were randomly assigned to a control(C)group,an aerobic ex-ercise(T)group and a resistance exercise(L)group. The rats of group T performed treadmill exercise 5 days per week for 8 weeks,while those of group L climbed vertical ladders with progressively in-creased weights once in 3 days for 8 weeks. All rats were weighed before and after the intervention.Then the bilateral interscapular brown adipose tissue was isolated and weighed at 48 h after the last ex-ercise. The hematoxylin–eosin staining was used to observe the morphology of adipocytes,and the quan-titative real-time PCR and Western blotting were employed to detect the m RNA and protein expressionof browning genes [PR-domain-containing 16(PRDM16),PPAR gamma coactivator-1α(PGC-1α)and uncoupling protein 1(UCP1)] respectively. Results After the intervention,the increment of weight of groupT and group L were only 52% and 70% of group C(P0.01 and P0.05). The weight of BAT in bothgroup T and L was lower than group C,but without significance(P0.05). The average size of lipiddroplets in group T decreased significantly(P0.01) and slightly in group L(P0.05) compared withgroup C. The PRDM16,PGC-1α and UCP1 m RNA expression of group T was 1.78(P0.01),2.2(P0.01) and 1.3(P0.05) times of group C,while that of group L was 1.30(P0.05),1.25(P0.05) and1.21(P0.05) times of group C. The PRDM16,PGC-1α and UCP1 protein level in group T was 1.46-fold(P0.05),1.56-fold(P0.05)and 1.20-fold(P0.05),while that of group L was 1.08-fold(P0.05),0.94-fold(P0.05) and 1.20-fold(P0.05) of group C. Conclusion Eight weeks of aerobic exercise cansignificantly make the lipid droplets of adipocyte smaller,increase the differentiation and metabolic activ-ity of BAT,and weakly stimulate BAT thermogenesis. However,8 weeks of resistance exercise has nosignificant effect on BAT.
【Fund】: 国家体育总局体育科学研究所基本科研业务费(15-28)
【CateGory Index】: R87
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