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《Acta Universitis Medicinalis Nahui》 2002-01
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Protective effects of Rutoside on experimental acute pancreatitis

Tian Jie, Zhao Weizhong, Wang Yuling et al (Dept of Pharmacology, Anhui Medical University, Hefei 230032)  
Objective To study the protective effects of Rutoside (Ru) on acute pancreatitis(AP) in rats. Methods AP models were induced by retrograde injection of sodium deoxycholate into bilipancreatic duct or by placing a ligature around the bilipancreatic duct at its point of entry into the duodenum in rat. Rats were injected subcutaneously with saline, Rutoside (30, 60, 120 mg/kg) or Octreotide (0.01 mg/kg) respectively before operation. The amylase (AMS) and lipase (LPS) activity was measured at 6,12 and 24 h after induction of AP. Survival rate at 24 h and pancreatic index were calculated. Pathomorphology of pancreaces was observed under microscope. Results It was shown AMS and LPS activity in Ru treated groups was much lower than that in model groups. 24h survival rate was enhanced in Ru 120 mg/kg group significantly. Pathologic study showed pancreatic leision was alleviated. Conclusion Ru has certain protective effects on AP.
【Fund】: 安徽省教育厅自然科学基金 (编号 :2 0 0 1kj 0 2 2 )
【CateGory Index】: R965
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