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《Acta Universitis Medicinalis Nahui》 2002-01
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The influences of Octreotide on rat liver regeneration undergone partial hepatectomy

Zou Weilong, Xu Geliang, Li Jiansheng et al (General Surgical Department, Anhui Medical University Provincial Hospital,Hefei 230001)  
Objective To assess the influences and security of Octreotide on rat liver regeneration and liver function undergone partial hepatectomy. Methods 80 male adult Wistar rats were divided into 5 groups, 16s in each group. Group A and B took only left lobe partial hepatectomy while Ocreotide (50 μg/kg)were administered intraperitoneally to group B twice a day. Walker-256 tumor was implanted in right lobe of liver of group C, D, E when their partial hepatectmoy of left lobe were operated. The first administered time for Octreotide on group D or E was 12 h and 72 h after resection respectively. Group A and C acted as blank and carrying control received a similar volume of saline. Results Each rat in weight of remnant liver, expression of PCNA, regenerative hepatic cell DNA content and liver function one week after resection were analyzed. There is no significant difference between A versus B or C, D versus E. Conclusion Octreotide has no significant suppression on hepatic cell regeneration without any relation with carrying tumor or not.
【CateGory Index】: R73-36
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