Effects of destruction and excitation of basolateral amygdaloid nuclei on behavioral activity in rats
Zhong Mingkui,Zhang Jin,Zhu Guoqing et al(Dept of Physiology,Anhui Medical University,Hefei 230032)
Objective To study the role of basolateral nuclei of amygdaloid body in regulating behavioral activity. Methods Sterotaxic surgery, microinjection,behavioral test were applied to investigate the behavioral activity of rats. Results Electrical lesions of bilateral BLN decreased locomotor activity and increased immobility time in the forced swimming test. Bilateral microinjection of kainic acid (KA, 0 5 μg) into BLN resulted the same effects. However,unilateral microinjection of L glutamate (L Glu, 0 1 μg) enhanced locomotor activity and shortened immobility time. Conclusion Destruction of BLN causes behavioral activity inhibiting effects;while excitation of BLN promoves behavioral activity.