Identification of differentially expressed genes in breast cancer by cDNA microarray
Zhang Linjie 1, Wang Xi 2, Luo Changmin 1 ( 1Dept of Immunology, Anhui Medical University, Hefei 230032; 2Tumor Hospital, Sun Yat Sen University, Guangzhou 510060)
Objective To investigate the profiling of differentially expressed genes in breast cancer and identify new candidate genes and molecular marks related to breast cancer. Methods Differentially expressed genes of breast cancer compared with the tissue near to breast cancer and normal breast tissue were investigated using high density cDNA microarray representing 14 000 cDNA clones. Results There were 80 differentially expressed genes between breast cancer and normal breast tissue, 57 between breast cancer and the tissue near to breast cancer, and 29 between the tissue near to breast cancer and normal breast tissue; 14 differentially expressed genes were found to be consistent when comparing breast cancer with the tissue near to breast cancer and normal breast tissue. Conclusion The present study represents a global view of gene expression of breast cancer and provides important clues for further study of breast cancer in Chinese women.