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The changes in the plasma true insulin and proinsul in level and its significance to obese ,impaired glucose tolerance and type 2 diabetic patients

ChenHaibing,YeShandong ,ChenYanetal (Dept of Endocrinology,An hui Provincial Hospital,Hefei 2 3 0 0 0 1 )  
Objective To study the changes and its significance of trueinsul in (TI) and proinsul in (PI)in obese ,impairedg lucose to leranceand type 2 diabetic patients.Methods 2 3cases with normalg lucose to lerance (NGT) ,3 5cases with impairedglucose to lerance (IGT) and 2 5cases with type 2 diabetic patient sweresub di vide in too besean dnon obese groups.TI and PIwer measured by ELIS Ausing monoclona lanti body with no significant cross reaction between in sulin and proinsul in .IRI was measured by RIA .Results The areasunder the curve of the TI ,PI ,IRI weresignifi cantlydif ferent between the obesegroup and non obese group .Thear easunder the curve of the TI and IRI of the obese group and non obese group with IGT ,obese group with NGT and obese group with DM weresignificantly higher than thenon obesegroupwithNGT .Whiletheareasunder the curve of the TI and RI of thenon obesegroup with 2 DMwere significantlylower than thoseof the non obese group with NGT .The areasunder the curve of thePI and PI/(PI±TI)of the obese group and non obese group with 2 DM werehigher than those of the non obese group with NGT ,butno difference between the group with IGT and thegroup with NGT .IS and ISI of the group with IGT weresignificantly higher than the group with 2 DM ,butsignificantl ylower than those of the group ith NGT .Therew ssignific antpos tive correla tionbetween fastingI RIandTIinth eobeseg roup with NGT ,IGT ,2 DMandin thenon obesegroup withIGT ,sowas between IS and ISI ,while there was signifi cantnegative correlation between fasting PIand IS.Conclusion The individuals with obesity,IGT ,obese type 2 DM havehyperin sulinemia .The patients with type 2 DM havedisproport ionalyincr ease dPI andPI/(PI±TI) .IRI mayoverestimat eins ulinlevelsin indivi dualswith bese,2 DMand IGT .Tosomee xtent ,PIcan estimatethefunc tionoftheisletbeta cell.
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