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《Acta Universitatis Medicinalis Anhui》 2006-01
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Expression and significance of myosin light chain kinase in the kidney of diabetic rats

Zhu Huaqing, Zhang Xiaolin, Wang Yangsheng et al (Laboratory of Molecular Biology and Dept of Biochemisty,Anhui Medical Unversity, Hefei 230032)  
Objective To study the expression and significance of myosin light chain kinase(MLCK) in the kidney of diabetic rats. Methods Diabetes was induced by intraperitoneal injection of streptozotocin(STZ 65 mg/kg body wt). Blood glucose were measured by an autoanalyser . The expression of MLCK was analyzed in renal tissue by immunohistochemistry and western-blot methods respectively. Results Plasma glucose of model group was significantly changed compared with that of the control group. The level of the MLCK was lower in renal tissue of 4-week diabetic rats than that in normal rats, whereas the changes were not obvious in kidney of model group treated with insulin in 4-week STZ-induced diabetic rats. Conclusion It is suggested that the formation of diabetic may be closely correlated with the low expression of MLCK in the diabetic rats. Insulin may play an important role in prevention of diabetic by increasing the expression of MLCK.
【Fund】: 国家自然科学研究基金(编号:03570750);; 安徽省高校优秀青年教师科研基金(编号:2004jq160);; 安徽省教育厅自然科学基金(编号:2004KJ211)资助
【CateGory Index】: R587.2
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 ZHU Hua-Qing, REN Bin 1, JIANG Zhi-Kui 2, ZHOU Qing, GUI Shu-Yu 3, WANG Yuan (Laboratory of Molecular Biology and Department of Biochemistry, Anhui Medical University, Anhui Province Key Laboratory of Genomic Research, Hefei 230032) 1Dept of Pathology, BIDMC & Harvard Medical School, 99Brookline, MA 02215, Boston, USA 2The 105th Hospital of Chinese Peoples Liberation Army, Hefei 230031 3Dept of Respiratory Disease, First Affiliated Hospital of AnHui Medical University, Hefei 230032;Effect of Vit E on myosin light chain kinase activity and expression in the liver of atherosclerosis model rabbit[J];Chinese Pharmacological Bulletin;2003-11
2 Ma Qiang, Wu Yonggui, Wu Guozhong et al (Dept of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022);LY333531 down-regulates the expression of connective tissue growth factor in the kidney of diabetic rats[J];Acta Universitis Medicinalis Nahui;2005-01
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 JIANG Zhi-Kui1,ZHU Hua-Qing,HU Yong1,WANG Jian1,ZHOU Qing,GUI Shu-Yu,WANG Yuan (Laboratory of Molelular Biology and Department of Biochemistry, Anhui Medical University, Hefei 2300321The 105th Hospital of Chinese Peoples LiberationArmy,Hefei230031);Effect of vitamin E on expression of myosin light chain kinase in the artery wall of atherosclerotic rabbits[J];Chinese Pharmacological Bulletin;2004-06
2 Wang Qiang, Wu Yonggui, Wu Guozhong, et al (Dept of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022);Effect of breviscapine on intercellular adhesion molecule-1 and monocyte chemotactic protein-1 expression in tubulointerstitium of experimental diabetic rats[J];Acta Universitatis Medicinalis Anhui;2006-01
3 Yuan Liang,Wu Yonggui,Liang Chao, et al(Dept of Nephrology, The First Affiliated Hospital, Anhui Medical University, Hefei 230022);Effect of the combination of enalapril and mycophenolate mofetil on the expression of connective tissue growth factor in kidney in diabetic rats[J];Acta Universitatis Medicinalis Anhui;2007-01
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