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《Acta Universitatis Medicinalis Anhui》 2006-01
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Therapeutic effects of intravenous infusion of rutoside on experimental AP

Wang Lin, Wu Zheng, Chen Zhiwu,et al(Dept ofPharmacology, Anhui Medical University, Hefei 230032)  
Objective To explore the therapeutic effects of intravenous infusion of rutoside (Ru) on experimentalacute pancreatitis (AP).Methods The AP model in rats was induced by retrograde injection of3% sodiumtauro-cholate into biliopancreatic duct. Ru at 15,30,60 mg/(kg·h) was administered by intravenous infusion for 6hours immediately after the induction of AP. The histopathological changes of pancreas were observed under micro-scope. Serum amylase, pancreatic weight, ascitic volume and amylase concentration in ascites in rats were deter-mined.Results Ru at15,30,60 mg/(kg·h) decreased the level of serum amylase and the amylase concentra-tion in abdominal liquor in AP rats by different degrees. Ru-treated groups significantly decreased the coefficient ofpancreas, ascites, interstitial edema and ameliorated inflammatory celluler infiltration.Conclusion Ru has certaintherapeutic effects on experimental AP by intravenous infusion.
【Fund】: 安徽省自然科学基金资助(编号:01043907)
【CateGory Index】: R285.5
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