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《Acta Universitatis Medicinalis Anhui》 2006-01
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Study of autologous atrial cells transplantation into the infarcted myocardium

Zhu Zhengyan, Yan Zhongya, Zhai Zhimin, et al (Dept of Cardiac Surgery, The Provincial Hospital of Anhui Medical University, Hefei 230001)  
Objective Study of the probability of autologous cells transplantation into the infarcted myocardium. Methods In 12 minitype adult swine a myocardial infarction was created by occlusion of the distal left anterior descending coronary artery by surgical ligation. Porcine heart cells were isolated and cultured from the left atrial appendage at the time of infarction and grown in vitro for 28 days. Through a sternotomy, either cells (n=6) or culture medium (n=6) was injected into the infarct zone. Left ventricular function was assessed by echocardiography immediately before transplantation and 4 weeks thereafter. Results The cells cultured in vitro include cardiomyoctes, smooth muscle cells, endothelial cells and fibroblasts. Four weeks after cells transplantation, echocardiography demonstrated greater EF value in the pigs receiving transplantation than in control animals. Conclusion Autologous atrial cells transplantation improves left ventricular function after a myocardial infarction. It may be the optimal cells for cellular cardiomyoplasty.
【Fund】: 安徽省自然科学基金安科医药专项资助项目(编号:01043711)
【CateGory Index】: R542.22
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