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《Acta Universitatis Medicinalis Anhui》 2006-01
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Experimental study on prevention of hormonally ischemic necrosis of femoral head in rabbits with combined use of Probucol and Aspirin

Liu debao,Bu haifu,Gui binjie (Dept of Orthopaedics, The First Affiliated Hospital of Anhui Medical University, Hefei 230022)  
Objective To investigate the effects of combination treatment with Probucol plus Aspirin on the prevention of steroid-induced avascular necrosis of femoral head(ANFH) in rabbits and to investigate the pathogenesis of ANFH. Methods Rabbits were divided randomly into three groups such as model group, treatment group and normal group. Before and after the experiment, serum lipid and prothrombin time (PT) were tested. In the 4th and 6th weeks of dexamethasone administration, the histopathological changes were observed with radiography, light microscopy and transmission electron microscopy. Results The incidence of osteonecrosis in the model group was 58%; the incidence of osteonecrosis in the treatment group(7%) was significantly lower than in the model group and no osteonecrosis was observed in the normal group. Under electron microscopy, osteocytes were found to be degenerative, necrotic and disappeared eventually. Conclusion Lipid metabolism disorder and hypercoagulability are risk factors for corticosteroid-induced osteonecrosis. This study experimentally confirms that the combined use of a lipid-lowering agent(Probucol) and an anticoagulant(Aspirin) prevents steroid-induced avascular necrosis of femoral head in rabbits.
【CateGory Index】: R681.8
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