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《Acta Universitatis Medicinalis Anhui》 2006-01
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Effect of breviscapine on intercellular adhesion molecule-1 and monocyte chemotactic protein-1 expression in tubulointerstitium of experimental diabetic rats

Wang Qiang, Wu Yonggui, Wu Guozhong, et al (Dept of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022)  
Objective To study the effect of breviscapine on intercellular adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein-1 (MCP-1) expression in tubulointerstitium of experimental diabetic rats. Methods Diabetes was induced by injection of streptozotocin after uninephrectomy. Rats were randomly separated into three groups such as control, diabetes, diabetes treated with breviscapine, and each group has 10 rats. 8 weeks after STZ injection, testing 24 hours albumin excretion rate (AER) and the activities of renal tissue protein kinase C (PKC) of each group were observed. The change of tubulointerstitial morphology was observed by PAS pigmentation. ED-1, ICAM-1 and MCP-1 expression in tubulointerstitium were tested by immunohistochemistry method. Results Increased AER and PKC activities in renal tissue were significantly attenuated by treatment with breviscapine. Tubulointerstitial injury index was reduced through breviscapine treatment compared with diabetic group. Increased macrophage recruitment as well as ICAM-1 and MCP-1 protein expression in tubulointerstitium were markedly inhibited by breviscapine in diabetic rats. Conclusion Breviscapine can inhibit increased macrophage recruitment. It may be caused by the suppression of increased expression of ICAM-1 and MCP-1 in tubulointerstitium in diabetic rats.
【Fund】: 安徽省自然科学基金资助课题(编号:01043703);; 安徽省教育厅高校中青年学科带头人基金资助课题(编号:522263)
【CateGory Index】: R285.5
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