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《Acta Universitatis Medicinalis Anhui》 2006-01
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The establishment of nonalcoholic steatohepatitis animal model

Wang Jianqing, Li Jun,Zou Yuhong, et al (School of pharmacy, Anhui Medical University, Hefei 230032)  
Objective To establish a rat model of nonalcoholic steatohepatitis. Methods The model rats were fed with high fat, high sucrose and high protein emulsion via gavage (from 2.5~10 ml/kg, once a day) and standard rodent chow adlibitum for 6 weeks. Serum levels of ALT, AST, TC, TG, HDL, LDL, hepatic TC and TG content and histopathologic changes of liver were evaluated. Results The serum levels of ALT, AST, HDL, LDL, TC, TG, hepatic TC and TG content in model rats were significantly higher than those in normal rats. The histopathological analysis suggested that the model rats developed panlobular steatosis and inflammatory cell infiltration. Conclusion A NASH model is successfully induced in rats by feeding with high fat, high sucrose and high protein emulsion via gavage .
【Fund】: 安徽省人才开发资金资助(编号:2004Z030)
【CateGory Index】: R-332
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