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《Acta Universitatis Medicinalis Anhui》 2006-01
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Synergistically suppressive effect of paeonol and cisplatin on the proliferation of human hepatoma cell line SMMC-7721

Xu Shuping, Sun Guoping, Wang Hua, et al (Institute of Clinical Pharmacology,Anhui Medical University,Hefei 230032)  
Objective To investigate the synergistically suppressive effect of paeonol and cisplatin on the proliferation of human hepatoma cell line SMMC-7721. Methods SMMC-7721 cells were cultured in regular condition and incubated with different concentrations of drugs. Cytotoxicity of the drugs was measured by MTT assay. The coefficient of drug interaction(CDI) was used to analyse the synergistically suppressive effect of drug combination. Results Paeonol(7.81~250 mg/L) and cisplatin(0.625~20 mg/L) had inhibitory effects on the proliferation of human hepatoma cell line SMMC-7721 in dose-dependent manner. The inhibitory rates of SMMC-7721 treated with combined agents were significantly higher than those treated with Paeonol and cisplatin alone. The synergistically suppressive effect was significant. Conclusion The results suggest that the combination of paeonol and cisplatin has obviously synergistically inhibitory effect on the proliferation of human hepatoma cell line SMMC-7721.
【Fund】: 安徽省自然科学基金项目(编号:050430901);; 安徽省教育厅自然科学基金重点项目(编号:2003Kj037zd);; 安徽省卫生厅自然科学基金项目(编号:2002A025)
【CateGory Index】: R735.7
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