Toxicity of selenium enriched yeast in mice, rats and dogs
Zhang Anping, Chen Shuhe, Wei Wei et al
The toxicities of selenium enriched yeast (SEY) were studied in animal experiments. In mouse, the maximal tolerance dose (ig) was higher than 6 400 mg·kg -1 and LD 50 (ip) was 122 06￣138 75 mg·kg -1 . Administered orally the doses of 100, 200 and 400 mg·kg -1 to rats, or 24, 240 mg·kg -1 to dogs on 45 consecutive days respectively, neither adverse effects were found in general physical signs, ECG, blood and urine tests, liver and kidney function tests, nor obvious toxicities produced in histopathological examination of twelve key organs. These results indicated that SEY did not produce any toxicity to the body during the long term administration.
【CateGory Index】： R977