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Study on Antitumor Activity of Phellinus vaninii in Vitro

CHENG Xin-ying1,BAO Hai-ying1,2,DING Yan3,YOUNG Ho Kim3(1.College of Chinese Medicinal Materials,Jilin Agricultural University,Changchun 130118,China;2.Engineering Research Center of Edible and Medicinal Fungi,Ministry of Education,Jilin Agricultural University,Changchun 130118,China;3.College of Pharmacy,Chungnam National University,Daejeon 305764,Korea)  
Antitumor activity of sakuranetin,7-methoxy-dihydrokaempferol,dihydrokaempferol,4-(3,4-dihydro-xyphenyl)-3-buten-2-one and hispolon from the fruiting body of Phellinus vaninii were studied by MTT method in vitro.The inhibitory rates of 4-(3,4-dihydroxy-phenyl)-3-butene-2-one and hispolon on SMMC-7721 cells were 34.83% and 48.09%,on MCF-7 cells were 71.09% and 74.57% at 100 μg/mL,respectively.The IC50 values were 69.48,61.57,30.22,24.68 μg/mL,respectively.4-(3,4-dihydroxy-phenyl)-3-butene-2-one and hispolon have good inhibitory effects on proliferation of SMMC-7721 cells and MCF-7 cells.
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