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《Chinese Journal of Hygiene Rescue(Electronic Edition)》 2017-06
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Clinical effect of Irinotecan plus ciplatin on treatment of retreated patients with advanced gastric cancer

Li Ying;Liu Fen;Department of pharmacy,Jiaozhou Municipal People’s Hospital;Information Department,Jiaozhou Municipal People’s Hospital;  
Objective To evaluate safety and clinical effects of Irinotecan( CPT-11) plus ciplatin( DPP) on treatments of advanced gastric cancer patients for whom first-line treatment failed. Methods A total of 60 patients with advanced gastric cancer were enrolled from June 2012 to June 2014 based on the inclusion and exclusion criteria. There were 41 males and 19 females,aged from 18 to 65 years with an average age of( 48. 91 ± 5. 77) years. The patients were randomly divided into two groups including CPT-11( 180 mg/m~2) treatment group and CPT-11( 180 mg/m~2) + DDP( 25 mg/m~2) group. After CPT-11 and CPT-11 + DPP treatments,clinical evaluation was performed by the detection of tumor markers,recent efficacy and long-term efficacy. Adverse events were also analyzed in this study. Results Compared with CPT-11 regimen,CPT-11 + DDP regimen had more effective in progression-free-sur( PFS) and the level of CA199 [( 220. 18 ± 59. 93) mg/L vs( 154. 12 ± 23. 77) mg/L],CEA [( 31. 24 ± 6. 15) mg/L vs( 15. 29± 3. 84) mg/L] and CA242 [( 50. 17 ± 5. 86) mg/L vs( 36. 46 ± 6. 44) mg/L] were significantly lower( P 0. 05). Butthere were no significantly differences in response rate( RR),disease control rate( DCR)and overall survival( OS). The occurrence rates of the adverse effects grade 3-4 events were leukopenia[18. 33%( 11/60) ],anemia[8. 33%( 5/60) ]and vomiting[5%( 3/60) ]in all regimens. The incidence rate of diarrhea of CPT-11 + DDP regimen was less than that of CPT-11 [46. 67%( 14/30) vs 16. 67%( 5/30),P 0. 05]. And,CPT-11 + DPP regimen had more fatigue [76. 67%( 29/30) vs 70. 00%( 21/30),P 0. 05] and vomiting [70. 00%( 21/30) vs 26. 67%( 8/30),P 0. 05]. Conclusion CPT-11 + DPP treatments significantly improve the patient 's PFS and reduce the expression of tumor markers and the incidence of diarrhea,but increase the incidence of vomiting and fatigue.
【CateGory Index】: R735.2
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