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《西安医科大学学报(英文版)》 1998-02
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CLINICAL AND EXPERIMENTAL STUDY OF DL-TETRAHYDROPALMATINE EFFECT IN THE TREATMENT OF SUPRAVENTRICULAR ARRHYTHMIA

Niu Xiaolin; Han Zhenhua; Ma Xin; Wang Shicken(Second Clinical Medical College, Xi'an Medical Uniwrsity, Xi'an 710004)  
Short-term efficacy and safety or dl-tetrahydropeimtine (dl-THP) effect in treatmentof supraventricularoremature beats (SVPS ) were studied with doubl-blind control. A 24h ambulato ry elettrocardiogram (Holier) was Performed to hudge the therapeutic efficacy before and after themedicatiou in all the 33 petients who took 300 mg/d, 450 mg/d, 600 mg/d dl-THP tblet in turn perweek. Total effective rate is 66. 7% ; more than 90% SVPBS disappear .in 18. 2% ; and more than75% SVPB. disappear in 48. 5%. Otherwise total affective rate is 13. 3% in placebo group. There issignificant differnce between the two groups (P 0. 01). The important adverse reactions areletharey (24' 2% ), occasional nausea and vomiting. We demonstrate that dl-THP can prolong A-Hinterval by determining His bundle,electrogram (HBE) in rabbits, so P-R interval lengthed can befound in surface ECG. Exploitation of dl-THP veinous preartion may be one of the,rfertove drugto treat paroxysmal supraventricular tacbycardia(PSVT).
【CateGory Index】: R541.7
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【Citations】
Chinese Journal Full-text Database 3 Hits
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 HAN Zhen-hua,NIU Xiao-lin,REN Fu-xian(The Cardiovascular Faculty of the Second Hospital,Xi'an Jiaotong University,Xi'an 710004,China);Effects of dl-tetrahydropalmatine on cardiac conduction cystem[J];Journal of Dalian Medical University;2006-04
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