Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Pharmacology and Toxicology》 1990-01
Add to Favorite Get Latest Update

Comparison between the effcts of gypenosides and ginsenosides on cardiac function and hemodynamics in dogs

CHEN Li-Feng,QIU Sai-Hong,LI Qun-Ai,HE Yong-Jian (Hunan Academy of Traditional Chinese Medicine and Materia Medico,Changsha 410006)  
The effects of gypenosides(Gyp)from Gynostema pentaphyllum(Thunb)Mak on the heart function and hemodynamics were studied in 8 anesthetized open chest dogs,in comparison with the action of ginsenosides(Gin)from Panax ginseng C.A.Mey.The arterial and left ventricular pressures were measured with a MPU-0.5 or CYS-0.5 pressure transducer and the cardiac output and the internal carotid arterial and coronary blood flows were measured with a MF-27 or MFV-1200 electromagnetic blood flowmctcr.The signal tracings were recorded on RM-86 polygraph.It was observed that Gyp 5 or 10 mg/kg iv,and Gin 10 mg/kg iv,significantly lowered systolic pressure,diastolic pressure and mean arterial pressure,andmarkedly decreased total peripheral vessel resistance,brain vessel resistance and coronary resistance.It was found that the coronary flow was raised and the heart rate was lowered by Gyp and Gin.The lowering of myocardiac oxygen consumption after the administration of Gyp and Gin could be explained by the decreasing of cardiac tension-time index and the slowing of heart rate.Nevertheless,it was insignificant that Gyp and Gin affected the myocardiac contractility and heart pump function.The effects of Gyp are slightly more potent than Gin.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 10 Hits
1 Liao DuanFang, Department of Pharmacology and Physiology, Hengyang Medical College;Effect of Gypenosides Against Oxidative Damage Part I, Influence of Gypenosides on Free Radicals Induced Injury of Guinea Pig Papillary Muscles And Rabbit Arterial Endothelium in Vitro[J];;1993-01
2 TCM Collage, Hebei Medical University CAO Li jing ZHANG Jiang hua XU Zhan min (Shingjiazhuang050091);Effect of Renshenqiangxindiwan on Heart Function of Heart-Failure Dog with Sodium Pentobarbital[J];Journal of Hebei Traditional Chinese Medicine and Pharmacology;2001-03
3 WU Ke-qin,ZHAO Huan-xin1,NIE Tian-tian1(Ji′nan Infectious Diseases Hospital,Ji′nan 250021;1.Institute of Materia Medica,Shandong Academy of Medical Sciences,Ji′nan 250062);Research progress on treating cardiovascular diseases with saponins in traditional Chinese medicine[J];Qilu Pharmaceutical Affairs;2009-09
4 Gao Ying-dong, Chen Wu, Xiong Xiao-juan, Li Kai-quan, Zou Sheng-qin, Institute of Biological Engineering, Yichun University, Yichun 336000, Jiangxi Province, China;Effects of Gypenosides on the stress ability of rats[J];Chinese Journal of Clinical Rehabilitation;2005-43
5 Jin Zhuqiu; Xu Mingzi;(Hunan College of Traditional Chinese Medicine, Changsha 410007);Effects of Gypenosides on the Isolated AtriaProperty of Gunia Pig[J];;1994-01
6 IU Li-Bo,HU Bi,LIAO Duan-Fang1 (Dept of Physiology; 1Dept of Pharmacology, Hengyang Medical College,Hunan 421001);Protective effect of gypenosides on free radical damage of isolated guinea pig papillary muscles[J];Chinese Pharmacological Bulletin;1993-04
7 Chen Gang;et al(Pepartment of Pathophysiology,Yunyang Medical,Shiyan 442000);Systemic and Pulmonary Hemodynamic Effects of Gypenosides in Anesthetized Dogs[J];Journal of Yunyang Medical College;1994-04
8 Chen Gang; Wang Xiong; Yu Juan; Li Li(Department of Pathophysiology, Yunyang Medical College,Shiyan(442000));Effects of gypenosides on hypoxic pulmonary vasoconstrictionin healthy men and anesthetised dogs[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1996-01
9 Zhou Jianzheng(Zhou JZ) ; Xiao Wenbin(Xiao WB) ; Zhang Fang(Zhang F) (Institute of pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850);Comparison of protective effects of gypenosides and ginsenosides on left ventricular relaxationduring acute myocardial ischemia in rats[J];CHINESE PHARMACEUTICAL JOURNAL;1996-04
10 Yu Juan Wang Xiong Chen Gang Dept.of Pathophysiology,Fujian Medical College,Fuzhou(350004) *Dept.of Pathophysiology,Yunyang Medical College,Hubei;Effects of Gypenosides on Ventricular Fibrillation Threshold and Plasma Thiobarbituric Acid Value in Rats[J];Chinese Journal of Integrated Traditional and Western Medicine;1995-S1
Chinese Journal Full-text Database 2 Hits
1 S hou Zhijuan ( Dept. of Histology & Embryology);EFFECT OF GYNOSAPONIN ON THE ABDOMINAL SUBCUTANEOUS MACROPHAGE IN MICE[J];Journal of Wenzhou Medical College;1989-04
2 Chen Gang; Wang Xiong; Yu Juan; Li Li(Department of Pathophysiology, Yunyang Medical College,Shiyan(442000));Effects of gypenosides on hypoxic pulmonary vasoconstrictionin healthy men and anesthetised dogs[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1996-01
Chinese Journal Full-text Database 10 Hits
1 XIANG Yan(Anhui Agricultural University,Hefei 230036);Effects of Hormone on Growth and Isozymes Activity of Gynostemma Callus in Vitro[J];AUHUI AGRICULTURAL SCIENCE BULLETIN;1999-03
2 Sun Feng et al (Wuhe Extension Center of Agriculture Technique, Wuhe 233300);Effect of Moisture in Soil on Jiaokulan Tea Growth[J];Journal of Anhui Agricultural Sciences;2001-02
3 Zhang Zhi(Department of Biological Engineering of Anhui Agricultural University,Hefei 230036 );A New Spccics of Gynostemma from China[J];JOURNAL OF ANHUI AGRICULTURAL UNIVERSITY;1995-02
4 Li Chun Zhou Liren (Department of Bioengineering,Anhui Agricultural University,Hefei 230036);Effects of Hormone on the Peroxidase and the Content of Gypenoside in Gynostemma Callus[J];JOURNAL OF ANHUI AGRICULTURAL UNIVERSITY;1998-04
5 Chen Qianfen;Tian Hecun;Zhang Chenyin;Chu Dekai;Yang Weidong(Department of Pathophysilolgy,Bengbu Medical College,Anhui 233003);Protective effect of gypenosides on global cerebral ischemia-reperfusion injury in rat[J];ACTA ACADEMIAE MEDICINAE BENGBU;1996-06
6 Lin Hua, Wang Zhongshan, Ji Guoyj, Zhao Dan, Zhao Xuejian(Department of Pathophysiology);EFFECT OF PANAXADIOL SAPONINS ON A II AND NE IN EXPERIMENTAL HEMORRHAGIC SHOCK[J];;1990-03
7 Zhong Guogan, Yue Gang, Shao Chunjie,Ma Xingyuan, Xu Jingda, Jiang Yan, Wang Xueqing(Dept. of Phyaiol., Dept. of Chem., N. Bethune Univ. of Med. Sci.) Dept. of Pathophysiol., Hebei Academy of Med. Sci.);DUAL-DIMENSIONAL EFFECT OF PANAXADIOL SAPONIN (PDS)ON ACTION POTENTIAL OF CULTURED CARDIAC CELLS[J];;1990-05
8 Wang Xiaoming, Zhong Guogan , Ma Xingyuan ,Jiang Yan, Zhang Wenjie , An Zhanyuan , Wang Zhongfeng(Central Laboratory of Physiology, Department of Physiology,Department of Organic Chemistry);CALCIUM CHANNEL BLOCKADE ACTION OF PANAXATRIOL SAPONINS ON THE L TYPE, T TYPE AND B TYPE CALCIUM CHANNELS OF CULTURED RAT CARDIOMYOCYTES[J];;1993-02
9 Chen Xia, Yang Shijie, Li Hong , Cao Yannian (Department of Pharmacology);EFFECT OF GINSENOSIDE MONOMER Rb, INJECTED INTO LH OF RATS ON BLOOD PRESSURE AND ITS MECHANISM[J];;1993-02
10 Chen Long, Zhong Guogan. Zhang Wenjie, Qi Hui, Sun Chengwen, Jiang Yan(Dept. of physiol. Cen. Lab. of Physiol. );Antioxidative damage action of panaxadiol monomer Rb_1 on cultured myocardiocytes[J];;1993-04
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 SHEN Hong-wei et al(College of Biological & Food Engineering,Dalian Polytechnic University,Dalian,Liaoning 116034);Study on the Optimum Extraction Condition of Gypenosides[J];Journal of Anhui Agricultural Sciences;2008-04
2 CHEN Xiao wen,FANG Zhao hui,CHENG Xiao yu (The First Affiliated Hospital,Anhui College of TCM,Anhui Hefei 230031,China);EFFECTS OF TANGKANGMING CAPSULE ON BLOOD GLUCOSE, BLOOD LIPIDS,HEMORRHEOLOGY IN DIABETIC RATS[J];Journal of Anhui Traditional Chinese Medical College;2001-05
3 MA Shan feng,LU Zong lan,GUAN Su dong,LIU Gui lan (Department of Physiology,Bengbu Medical College,Anhui 233003 ,China) [;Antagonistic effect of gypenoside on diaphragm against doxorubicin cytotoxicity[J];JOURNAL OF BENGBU MEDICINAE COLLEGE;2000-05
4 LIN Ru 1,2 ,CAO Yu fang 2,HU Zheng hai 2* (1 College of Life Science,Fujian University of Agriculture and Forestry,Fuzhou 350002,China;2 Institute of Botany,Northwest University,Xian 710069,China);Anatomical structure of vegetative organs and histochemical localization of ginsenosides in Gynostemma pentaphyllum[J];Acta Botanica Boreali-occidentalia Sinica;2002-04
5 LIN Ru 1.2 , LIU Shi biao 1,CAO Yu fang 1,HU Zheng hai 1* (1 Institute of Botany, Northwest University, Xi'an 710069 China; 2 College of Life Science, Fujian University of Agriculture and Forestry, Fuzhou 350002 China);Studies on the correlation between the content of gypenosides and its vegetative organs and growth period[J];Acta Botanica Boreali-occidentalia Sinica;2003-07
6 HOU Hui-li~1,WANG Bao-li~1,GUO Yun-cheng~2,MAO Jianxiang~2,FU Tong-sheng~1(College of Animal Medicine,HNAU,Changsha,Hunan,410128,China;2.Taojiang Institute of Gynostemma Pentaphyllum,Yiyang,Hunan,413517,China);Effect of "Nanshen Xubao" on Activities of Serum Enzymes and Lactate Dehydrogenase Isozyme-Spectra in Finishing Pigs[J];Progress in Veterinary Medicine;2006-07
7 HOU Hui-li,FU Tong-sheng(College of Animal Medicine,Hunan Agricultural University,Changsha,Hunan,410128,China);Research Advance in the Chemical Ingredients and Pharmacological Effects of Gynostemma pentaphyllum[J];Progress in Veterinary Medicine;2006-S1
8 ZHU Lian-cai1,WANG Bo-chu1,TAN Jun1,2(1.Key Laboratory for Bioengineering & Tissue Engineering Under the State Ministry of Education,Bioengineering College,Chongqing University,Chongqing,400030,China;2.Department of Life Science and Chemistry,Chongqing Education College,Chongqing 400067,China);Effect of Ginkgo biloba extract and ginsenosides on the Vascular Activity Substance production in endothelium cells[J];Journal of Chongqing University(Natural Science Edition);2007-04
9 HUI Rui-hua, HOU Dong-yan, LI Tie-chun, LIU Xiao-yuan Department of Chemistry, Anshan Normal University, Anshan 114005, China;Simultaneous Determination of Total Flavone and Total Saponin in Gynostemma Pentaphyllum by Signal Multiplier Spectrophotometry[J];Spectroscopy and Spectral Analysis;2006-09
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved