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《Chinese Journal of Pharmacology and Toxicology》 1990-01
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Comparison between the effcts of gypenosides and ginsenosides on cardiac function and hemodynamics in dogs

CHEN Li-Feng,QIU Sai-Hong,LI Qun-Ai,HE Yong-Jian (Hunan Academy of Traditional Chinese Medicine and Materia Medico,Changsha 410006)  
The effects of gypenosides(Gyp)from Gynostema pentaphyllum(Thunb)Mak on the heart function and hemodynamics were studied in 8 anesthetized open chest dogs,in comparison with the action of ginsenosides(Gin)from Panax ginseng C.A.Mey.The arterial and left ventricular pressures were measured with a MPU-0.5 or CYS-0.5 pressure transducer and the cardiac output and the internal carotid arterial and coronary blood flows were measured with a MF-27 or MFV-1200 electromagnetic blood flowmctcr.The signal tracings were recorded on RM-86 polygraph.It was observed that Gyp 5 or 10 mg/kg iv,and Gin 10 mg/kg iv,significantly lowered systolic pressure,diastolic pressure and mean arterial pressure,andmarkedly decreased total peripheral vessel resistance,brain vessel resistance and coronary resistance.It was found that the coronary flow was raised and the heart rate was lowered by Gyp and Gin.The lowering of myocardiac oxygen consumption after the administration of Gyp and Gin could be explained by the decreasing of cardiac tension-time index and the slowing of heart rate.Nevertheless,it was insignificant that Gyp and Gin affected the myocardiac contractility and heart pump function.The effects of Gyp are slightly more potent than Gin.
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