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《Chinese Journal of Clinical Pharmacology and Therapeutics》 2005-08
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Effects and mechanisms of ginsenoside Rg1 on learning and memory impairment induced by scopolamine hydrobromide

CHEN Xin-mei, ZHU Jia-bi Institute of Pharmaceutical, China Pharmaceutical University, Nanjing 210009, Jiangsu, China  
AIM: To study the protective effects of ginsenosides Rg1 liposome (Rg1-L)on learning and memory impaiment induced by scopolamine hydrobromide in rats, and discuss the relevant mechanisms. METHODS: AD model was made by scopolamine hydrobromide. Y-maze was used to detect the learning and memory abilities. The active of acetylcholinesterase(AchE) in the brain of rats was measured. RESULTS: Rg1-L obviously improved the learning and memory abilities of AD rats and restrained the activity of AchE. CONCLUSION: Rg1-L improves the learning and memory abilities of AD. The relevant mechanisms may be related to restraining the activity of AchE, improving the lipophilic activity of Rg1 by liposome and bio avalbility.
【CateGory Index】: R285
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