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《Journal of Diffcult and Complicated Cases》 2003-01
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Changes of antioxidation ability in rabbit with acute renal failure

ZHAO Zigang *,ZHANG Xiuchang,NIU Chunyu,et al. *Department of Pathophysiology,Zhangjiakou Medical College,Zhangjiakou 075000,China  
Objective To inquire into the changes and meanings of antioxidation ability in rabbits with acute renal failure(ARF).Methods 30 rabbits were randomly divided into two groups:the control group(n=15),the ARF group(n=15).The ARF model of rabbit was copied by 1% HgCl 2,the malondialdehyde(MDA),superoside dismutase(SOD)content in serum and renal homogenate were determined by modificatory TBA microdetermination,xanthinoxidanse method.Results It showed that MDA content in serum and renal homogenate of ARF group was significantly increased than that of control group (P0.01),and the SOD content was signifcantly lower than that of control group(P0.01).Conclusion The results suggested that the antioxidation ability decreased obviously in acute renal failure.
【Fund】: 张家口市科委资助项目 (NO :0 11114 )
【CateGory Index】: R692.5
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