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《Journal of Diffcult and Complicated Cases》 2003-02
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Effect of combined treatment of traditional Chinese and western medicine on the apoptosis of CD_(34)~+ cells in patients with chronic aplastic anemia

SUN Xujiang,WANG Shuqing,LI Jianhua. Affiliated Hospital of Weifang Medical College,Shangdong,Weifang 261031,China  
Objective To investigate the therapeutic effect of combined treatment of traditional Chinese and western medicine on chronic aplastic anemia (CAA) and to explore its mechanism.Methods 79 patients with CAA were randomly divided into two groups. 39 patients in control group were treated with western medicine;40 patients in treatment group were treated by combined treatment of traditional Chinese and western medicine. The bone marrow CD 34 + cells were isolated by MACS,and the in situ apoptosis of bone marrow CD 34 + cells was analyzed by TUNEL.Results The cure rate, remission rate and total effective rate in treatment group were 37.50%,25.00% and 87.50% respectively; those in control group were 20.51%,17.95% and 61.54% respectively. There was a significant difference between two groups (P0.01). The apoptosis rate of bone marrow CD 34 + cells in treatment group after treatment was significantly decreased ,compared with that in control group (P0.01).Conclusion The combined treatment of traditional Chinese and western medicine is effective in the treatment of CAA, with less side effects. The action mechanism may be inhibiting the apoptosis of hematopoietic cells and reconstructing hematopoietic function of bone marrow.
【Fund】: 国家中医药管理局科研基金资助课题 (课题号:0 0 -0 1LP37) ;; 山东省科委科研基金资助课题(课题号:9712 2 6 2 0 9)
【CateGory Index】: R556.5
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