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《Journal of Diffcult and Complicated Cases》 2003-02
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Effect of combined treatment of traditional Chinese and western medicine on the apoptosis of CD_(34)~+ cells in patients with chronic aplastic anemia

SUN Xujiang,WANG Shuqing,LI Jianhua. Affiliated Hospital of Weifang Medical College,Shangdong,Weifang 261031,China  
Objective To investigate the therapeutic effect of combined treatment of traditional Chinese and western medicine on chronic aplastic anemia (CAA) and to explore its mechanism.Methods 79 patients with CAA were randomly divided into two groups. 39 patients in control group were treated with western medicine;40 patients in treatment group were treated by combined treatment of traditional Chinese and western medicine. The bone marrow CD 34 + cells were isolated by MACS,and the in situ apoptosis of bone marrow CD 34 + cells was analyzed by TUNEL.Results The cure rate, remission rate and total effective rate in treatment group were 37.50%,25.00% and 87.50% respectively; those in control group were 20.51%,17.95% and 61.54% respectively. There was a significant difference between two groups (P0.01). The apoptosis rate of bone marrow CD 34 + cells in treatment group after treatment was significantly decreased ,compared with that in control group (P0.01).Conclusion The combined treatment of traditional Chinese and western medicine is effective in the treatment of CAA, with less side effects. The action mechanism may be inhibiting the apoptosis of hematopoietic cells and reconstructing hematopoietic function of bone marrow.
【Fund】: 国家中医药管理局科研基金资助课题 (课题号:0 0 -0 1LP37) ;; 山东省科委科研基金资助课题(课题号:9712 2 6 2 0 9)
【CateGory Index】: R556.5
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【References】
Chinese Journal Full-text Database 1 Hits
1 LIU Weixia The Frist Affiliated Hospital of Henan College of TCM,Zhengzhou 450000,China;Clinical Effect of Zao Sheng Xue Granules on Chronic Aplastic Anemia[J];Journal of Medical Forum;2007-06
【Citations】
Chinese Journal Full-text Database 3 Hits
1 Wang Shuqing et al. (Affilicated Hospital of Wei fang Medical College, Shandong);Effect of “Bushen Huayu Decoction” on Ag-NORs of Patients with Chronic Aplastic Anemia[J];China Journal of Traditional Chinese Medicine and Pharmacy;1997-01
2 Wang Shuqing, Zhang Shengming, Li Jianhua, et al Affiliated Hospital of Weifang Medical College, Shandong (261031);Effect on Life Span and Membrane Protein in Red Blood Cells by Integrated Medicine Therapy on Chronic Aplastic Anemia[J];Chinese Journal of Integrated Traditional and Western Medicine;1998-05
3 WANG Shu-qing;LI Jian-hua;ZHANG Sheng-ming;et al(The Affiliated Hospital of Weifang Medical College,Shandong 261031);Effect of Bushen Huayu Recipe on DNA Content of Myeloid Cells in Aplastic Anemia Patients[J];CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE;1996-07
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Li Guixiang (The Second Hospital of Lanzhou Medical College,Lanzhou 730030);Clinical Application of Determination of Tumor Necrosis Factor and Interleukin-2 in Lung Cancer Patients[J];LABELED IMMUNOASSAYS AND CLINICAL MEDICINE;1999-02
2 Huang Zhenqiao( Yue Yang Hospital Attached to Traditional Chinese Medicine Integrated TCM and WesternMedicine in Shanghai);The Influence of the Prescription which Nourishes Kidney and Clears the Livers of Pathogenic Fire on Peripheral Blood of Aplastic Anemia[J];China Journal of Traditional Chinese Medicine and Pharmacy;2001-06
3 LIANG Hou jie, LI Jian jun, HU Shao yi (Department of Oncology and Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China);Protective effects of ligustrazine on murine bone marrow stromal cells damage in mice after high-dose chemotherapy[J];Acta Academiae Medicine Militaris Tertiae;2002-11
4 Liang Bing (Hebei Provincial Langfang Hospital of TCM, Langfang 065000);Thinking and Ways of TCM in the Treatment of Aplastic Anemia[J];HUNAN GUIDING JOURNAL OF TRADITIONAL CHINESE MEDICINE AND PHARMACOLOGY;1999-11
5 YANG Guo hua 1, YANG Bi yun 2, XIONG Hong 3, LI Hui hui 2 (1.Department of Hematology, the First People's Hospital of Wuxi, Wuxi 214002, China; 2.Department of Hematology, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang 330006, C;Studies of Cellular Immune and its Influence on Bone Marrow Hemapoietic Function in Aplastic Anemia Patients[J];Acta Academiae Medicinae Jiangxi;2000-04
6 Zhu Yuelan , Sun Weizheng (The Second Affiliated Hospital of Beijing University of Traditional Chinese Medicine, Beijing 100078);Clinical Study of the Treatment of Chronic Aplastic Anemia with Busuishengxue Capsules[J];JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1998-05
7 Qiu Zhongchuan , Zhao Lin , Chen Pei , et al. (Shuguang Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200021);Study of the Effects of Bushen Compound Instant Granules on the Hematopoietic Progenitor Cells in the Patients with Aplastic Anemia[J];Journal of Beijing University of Traditional Chinese Medicine;2001-03
8 Su Wei,Chen Li,Zhu Yuelan,et al( Dongfang Hospital, Beijing University of TCM, Beijing 100078);Treatment of Severe Aplastic Anemia with Therapy of Replenishing Qi and Blood Combined with Stanozolol[J];Journal of Beijing University of Traditional Chinese Medicine(Clinical Medicine);2005-01
9 ZHANG Xiangzhong 1 HONG Wende 1 PENG Aihua 1 ZANG Guocai 1 LUO Shaokai 1 TONG Xiuzhen 1 XU Duorong 1 AN Yehao 1 ( 1Department of Hematology,Internal Medicine,First Affiliated Hospital, zhong shan University ,Guangzhou,510080);Relationship between aplastic anemia and Fas-Fasl system and apoptosis[J];Journal of Clinical Hematology;2002-01
10 LI Xiaolong 1 CHENG Xiaodong 1 WANG Huaguo 1 WANG Yalin 1 ( 1Department of Laboratory Medicine,the First Affiliated Hospital of Wenzhou Midical College, Wenzhou, Zhejiang 325000,China);Clinical significance of NO and cytokines in aplastic anemia[J];Journal of Clinical Hematology;2004-01
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 CHEN Le,LI Yu-yun,HAO Yan-mei,et al.Bengbu Medical College,Bengbu Anhui 233000,China.;The effect of Bushen-Shengxue herbs on TSH,T_3,T_4,ACTH and COR levels in patients with chronic aplastic anemia[J];Journal of Clinical and Experimental Medicine;2011-10
2 LIU Ping1,2,QIN Xiao-tian3,ZHU Chuan-jiang1(1.Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;2.College of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China;3.Beijing Tian Yu Yi Ming Biotechnology Company Limited,Beijing 100078,China);Observation of Effects of Tianshengyuan Oral Solution in Mice with Immune-Mediated Aplastic Anemia[J];Chinese Journal of Experimental Traditional Medical Formulae;2011-23
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 Yan Dexin (Shanghai Railway Central Hospital, Shanghai);Deficiency of Qi and Stagnancy of Blood——an Important Mechanism of PhysicaI Senility[J];;1989-02
2 Xie Jinyu, Liu Mingfu, Huang Weiquan, Wen Chuan(Department of Cytology, Institute of Basic Theories of TCM, ChinaAcademy of Traditional Chinese Medicine, Beijing);MEASUREMENT OF DNA CONTENTS OF NORMAL AND CARCINOMATOUS CELLS IN SITU OF HUMAN MAMMARY GLAND[J];Acta Anatomica Sinica;1987-01
3 Guo Wenjun, et al Department of Pathology;SILVER—BINDING NUCLEOLAR ORGANIZER REGIONS IN NON—HODGKINS LYMPHOMA[J];Acta Academiae Medicinae Weifang;1990-04
4 Chu Yuling, et al;Preliminary Evaluation of RBC Survival Time and Destruction Site Determination in Aplastic Anemia[J];Tianjin Medical Journal;1984-01
5 Jiang Wen-yue;Li Shun-cheng;Wang Chuan-she;et al(Beijing Medical University,Beijing 100083);Mechnism of Tonifying Kidney and Removing Blood Stasis Recipe in Modulation of Immune Senescence[J];CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE;1995-06
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