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《Chinese Journal of Difficult and Complicated Cases》 2006-06
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A control study of Tongxinluo capsule in combination with aspirin to prevent cerebral thromboembolism due to nonvalvular atrial fibrillation

JIN Chen-ting,ZHOU Xiao-zhou,ZHU Gui-ping,et al.Department of Cardiology,The First Affiliated Hospital of GuangDong Pharmaceutical University,Guangzhou 510080,China  
Objective To compare the effect and safety of Tongxinluo capsule combined with aspirin,warfarin and aspirin to prevent cerebral thromboem bolism due to nonvalvular atrial fibrillation(NVAF).Methods One hundred and fifty patients with NVAF were randomly divided into three groups.The patients of Tongxinluo capsule in combination with aspirin group (n=50) took orally Tongxinluo capsule (0.76 g,3 times a day) and aspirin (0.1g/day);Patients of warfarin group (n=50) took orally warfarin,The range of dosage was 1.25~5.0 mg/day and kept the INR between 1.8 and 2.5;Patients of aspirin group (n=50) took orally aspirin (0.1 g/day).The primary diseases of all patients were treated.The incidence of cerebral thromboembolism and the side effects were followed up during 2 years.Results The incidence of cerebral thromboembolism in Tongxinluo capsule combined with aspirin group (6.0%/year) was significantly lower than that in aspirin group (15.0%/year,P0.05),The incidence of cerebral thromboembolism in aspirin group was significantly higher than that in warfarin group (P0.01),but there was no difference between Tongxinluo capsule combined with aspirin group and warfarin group (3.0%/year,P 0.05 ).The incidence of hemorrage in warfarin group was 2.0%/year (n=2) and it was zero in the other two groups.Conclusion The effect of Tongxinluo capsule in combination with aspirin to prevent cerebral thromboembolism due to NVAF is same to that of warfarin and significantly better than that of aspirin. Tongxinluo capsule in combination with aspirin to prevent cerebral thromboembolism due to NVAF is safe,and it does not need detecting INR.
【CateGory Index】: R541.75;R743.3
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