Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Difficult and Complicated Cases》 2006-06
Add to Favorite Get Latest Update

A control study of Tongxinluo capsule in combination with aspirin to prevent cerebral thromboembolism due to nonvalvular atrial fibrillation

JIN Chen-ting,ZHOU Xiao-zhou,ZHU Gui-ping,et al.Department of Cardiology,The First Affiliated Hospital of GuangDong Pharmaceutical University,Guangzhou 510080,China  
Objective To compare the effect and safety of Tongxinluo capsule combined with aspirin,warfarin and aspirin to prevent cerebral thromboem bolism due to nonvalvular atrial fibrillation(NVAF).Methods One hundred and fifty patients with NVAF were randomly divided into three groups.The patients of Tongxinluo capsule in combination with aspirin group (n=50) took orally Tongxinluo capsule (0.76 g,3 times a day) and aspirin (0.1g/day);Patients of warfarin group (n=50) took orally warfarin,The range of dosage was 1.25~5.0 mg/day and kept the INR between 1.8 and 2.5;Patients of aspirin group (n=50) took orally aspirin (0.1 g/day).The primary diseases of all patients were treated.The incidence of cerebral thromboembolism and the side effects were followed up during 2 years.Results The incidence of cerebral thromboembolism in Tongxinluo capsule combined with aspirin group (6.0%/year) was significantly lower than that in aspirin group (15.0%/year,P0.05),The incidence of cerebral thromboembolism in aspirin group was significantly higher than that in warfarin group (P0.01),but there was no difference between Tongxinluo capsule combined with aspirin group and warfarin group (3.0%/year,P 0.05 ).The incidence of hemorrage in warfarin group was 2.0%/year (n=2) and it was zero in the other two groups.Conclusion The effect of Tongxinluo capsule in combination with aspirin to prevent cerebral thromboembolism due to NVAF is same to that of warfarin and significantly better than that of aspirin. Tongxinluo capsule in combination with aspirin to prevent cerebral thromboembolism due to NVAF is safe,and it does not need detecting INR.
【CateGory Index】: R541.75;R743.3
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 4 Hits
1 LI Shu-ren *,QI Xiao-yong,ZHAO Yong-jun,Gu Jian,ZHANG Jian-qing, WANG Tian-hong,WANG Jin-hua,WANG Xiao-ping *Department of Heart Center, Hebei Provincial People's Hospital, Shijiazhuang 050051, China;Effect of Tongxinluo on endothelium-dependent vasodilatation in coronary artery disease[J];Clinical Focus;2004-15
2 SUN Shangwen,ZHAO Yuxia,LIANG Jile.Qilu Hospital of Shandong University,Ji'nan 250012,China;Effect of Tongxinluo capsule on the function of platelet activation in patients with unstable angina pectoris[J];Journal of Diffcult and Complicated Cases;2004-05
3 HU Da yi *,SUN Yi hong, ZHOU Zi qiang, LI Kui bao, NI Yong bin, YANG Guang, SUN Shu hong, LI Lei *Cardiology Department of Renmin Hospital, Peking University, Beijing 100044, China;Risk factors for stroke in Chinese with non valvular atrial fibrillation:a case-control study[J];Chinese Journal of Internal Medicine;2003-03
4 Society of Cardiology, Chinese Medical Association, Beijing, China Department of Cardiology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China;Retrospective investigation of hospitalized patients with atrial fibrillation in major parts of China[J];Chinese Journal of Cardiology;2003-12
Chinese Journal Full-text Database 10 Hits
1 SONG Zi-kai1,QU Rui1,QIN Ling1,HUANG Ke-xin2(1.Department of Cardiology,First Hospital,Jilin University,Changchun 130021,China;2. Department of Histology and Embryology,School of Basica Medical Sciences,Jilin University,Changchun 130021,China);Anti-atherosclerosis effect of Tongxinluo in rabbits and its mechanism[J];Journal of Jilin University(Medicine Edition);2010-01
2 HAN Wei, SHEN Dan-tong, WANG Yu-mei Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010, China;Comparative study of warfarin and aspirin for stroke prevention in elderly patients with atrial fibrillation[J];Journal of Southern Medical University;2006-06
3 CAO Hong-yan1, QIN Ling1, HUANG Ke-xin2 Department of Cardiology, First Huspital1, Department of Histology and Embryology, School of Basic Medical Sciences2, Jilin University, Changchun 130021, China;Effects of Tongxinluo on MMP-3, 9 and PPAR_γ expressions in atherosclerotic rabbits[J];Journal of Southern Medical University;2009-09
4 XU Jianran1),LU Beijun2),CHEN Xiaoying1),CEN Zhenbo1),HU Yujian1),GONG Shifeng3),ZHOU Jianqing4),CHEN Junzhu5).1)Department of Cardiology,the People's Hospital of Cixi,Cixi 315300,Zhejiang;2)The Third People's Hospital of Cixi;3)The Second People's Hospital of Cixi;4) The Affiliated Lihuili Hospital,Medical College of Ningbo University;5)Department of Cardiology,the Affiliated First Hospital,Medical College of Zhejiang University;Randomized study of efficiency and safety of antithrombotic therapy with warfarin in nonvalvular atrial fibrillation[J];Clinical Medicine;2008-06
5 Yao Enda,Chen Hong.Fujian Provincial Hospital,Fuzhou 350001,China;Investigations of ARB's effects on atrial electrical remodeling of hypertension patients:Analysis of 64 cases[J];Fujian Medical Journal;2005-05
6 LI Bi-qiang,YAO En-hui(Union Hospital,Fujian Medical University,Fuzhou,Fujian 350001,China);Effect of Tongxinluo on Expression of Plasma NO,Endothelin and iNOS mRNA in Vascular Smooth Muscle in Spontaneously Hypertensive Rats[J];Journal of Fujian University of Traditional Chinese Medicine;2009-04
7 LI Jun//Xi Qiao People's Hospital of Foshan City,Foshan 528211, China;Clinical observation of Tongxinluo capsule combined with low-molecular-weight haparin calcium in treating unstable angina pectoris[J];Acta Medicinae Sinica;2005-04
8 YU Qing;LI Yan-juan(The Sixth Hosptial of Chengde City,Hebei Chengde 067200,China);The Clinical Study of Treating 32 cases Coronary Heart Disease with Tongxinluo Capsule[J];Hebei Medicine;2008-06
9 FU Shi-ying,FU Bing,DONG Li-hang,et al.(Department of Cardiology,The First Clinical Medical Hospital Affiliated of Harbin Medical University,Harbin 150001,China);The Investigation of Anticoagulation Therapy with Warfrin in Patients with Atrial Fibrillation to Prevent Cerebral Embolism[J];Heilongjiang Medical Journal;2009-10
10 ZHANG Qi,CHE Lin,CHEN Xiao-guang(Department of Neurology,the Daowai Branch of the Hospital of Helongjiang Province,Harbin 150056,CHINA);Atrial Fibrillation and Ischemic Stroke[J];Heilongjiang Medical Journal;2010-04
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 Wang Peng;Zhang Ying;Fan Yaming;et al.(Beijing Heart Lung &Blood Vessel Medical Center 100029);The Influence of Hirudo and Red Sage Root on Atherogenesis and Fibrinolytic System in Rabbits[J];JOURNAL OF CARDIOVASCULAR AND PULMONARY DISEASES;1996-01
2 ZHAO Ming zhong,GAO Chen mei,ZHANG Yu yang Department of Cardiology,Xuan Wu Hospital,Cpital university of Medical sciences,Beijing,100053;Experimental study in protective action of Tong xin luo Capsule on myocardial ischemia/reperfusion injury.[J];CHINA JOURNAL OF BASIC MEDICINE IN TRADITIONAL CHINESE MEDICINE;2000-01
3 LIU Jianxun;SHANG Xiao-hong; WANG Gang; et al (Department of Basic Medicine, Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091);Effect of Tongxinluo Capsule on Experimental Myocardial Ischemia, Arrhythmia and Hyperlipidemia[J];Chinese Journal of Integrated Traditional and Western Medicine;1997-07
4 SHANG Xiao hong; WANG Gang; LIU Jian-xun; et al (Department of Basic Medicine, Xiyuan Hospital, China Academy ofTraditiond Chinese Medicine, Beijing 100091);Effects of Tongxinluo Capsule on Hemodynamics and Myocardial Oxygen Consumption in Dogs[J];Chinese Journal of Integrated Traditional and Western Medicine;1997-08
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved