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《Chinese Journal of Difficult and Complicated Cases》 2006-06
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Relationship between the dosage and efficiency of naloxone in the treatment of acute cerebral infarction

YANG Yong-sen,TAO Xia,ZHONG Ze-qing,et al.Center of Difficult and Complicated Disease,Affiliated Taihe Hospital of Yunyang Medical College,Hubei,Shiyan 442000,China  
Objective To observe the relationship between the dosage and efficiency of naloxone in the treatment of acute cerebral infarction(ACI) and explore its best dosage for the treatment of ACI.Methods 60 patients with ACI were randomly divided into 4 groups.They were treated with different dosage of naloxone (1.6 mg,2.8 mg,3.6 mg,5.2 mg) by intravenous drip for 14 days,respectively.The clinical therapeutic effect in each group was observed and the curve of relationship between the dosage and efficiency was drawn.Results No effect was found with the dosage of 1.6 mg naloxone;the symptoms got better slightly with the dosage of 2.8 mg naloxone, its curve was at the ascending stage; obvious effect was exhibited with 3.6 mg naloxone, its curve was at rapidly ascending stage;the effect was the best with the dosage of 3.6 mg to 5.2 mg naloxone,but the ascending tendency of the curve became less.Conclusion The best dosage of naloxone to treat acute cerebral infarction may be at the range of 3.6~5.2 mg.
【CateGory Index】: R743.34
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