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《Chinese Journal of Difficult and Complicated Cases》 2006-06
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Efficacy and safety of combined therapy with simvastatin and fenofibrate for type 2 diabetes patients with mixed hyperlipidemia

XIONG Xin-zhong,LI Jin-hai,CHEN Xiao-yun.Department of Cardiology,The People's Hospital of Zhongxiang City,Hubei Province,Zhongxiang 431900,China  
Objective To investigate the efficacy and safety of combined therapy with simvastatin and fenofibrate for type 2 diabetes patients with combined hyperlipidemia.Methods Eighty type 2 diabetes patients with mixed hyperlipidemia were randomly divided into two groups.The patients in group A were administered simvastatin (10 mg/d) and fenofibrate (200 mg/d)during six months,the patients in group B took orally simvastatin (20 mg/d) for six months.The blood lipid were determined before and after treatment,and side effects were observated during the period.Results Comparing with those before treatment,the decreasing degree of TC,LDL and TG were separately 31%,38% and 55%,the level of HDL increased 22% in group A,They were 21%,28%,10% and 5% in group B,there was signifcant difference between the two groups (P0.01).There was no difference about the rate of side effects during the period between the two groups (P0.05).Conclusion Combined therapy with simvastatin and fenofibrate for type 2 diabetes patients with mixed hyperlipidemia could be safe and more effective.
【CateGory Index】: R587.1;R589.2
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