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《Chinese Journal of Difficult and Complicated Cases》 2006-06
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A randomized comparative study of ACEI and combinated treatment with ACEI and ARB in hypertensive patients with heart failure

LIU Ya-lin,MA Jing-tao,SUN Fang-yi,et al.Department of Cardiology,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China  
Objective To evaluate the safty and efficacy of ACEI and combinated with ACEI and ARB for hypertensive patients with heart failure.Methods From Feb.2005 to Feb.2006,91 hypertensive patients with heart failure were randomized to receive ACEI ( perindopril,4 mg/day,n=46) and combinated with ACEI and ARB (perindopril,4 mg/day ;Valsartan,80 mg/day,n=45 ).All patients taken hydrochlorothiazide (25 mg/day ).Heart function,serum creatinine,CRP and electrolytes were measured before,1 month after treatment.Results (1) No one was higher in the level of K~+ and creatinine after treatment.(2) There was significantly difference in the level of CRP between before and after treatment (P0.05 ).Differences of CRP were found between two groups (P0.05 )after treatment.(3) The systolic function was significantly different after treatment (P0.05 ).Otherwise,no difference was found between two groups (P0.05 ).(4) Differences of the diastolic function were found between before and after treatment (P0.05 ).There was difference between two groups after treatment (P0.05).Conclusion Our results suggest that combinated treatment with ACEI and ARB on hypertensive patients with heart failure is effective and safe by taken hydrochlorothiazide in the meantime.Combinated treatment with ACEI and ARB can improve the effect in control of hypertension.That did not increase serum K+ and creatinine levels.CRP was significantly reduced compared to the ACEI group after treatment.So,combinated treatment with ACEI and ARB can improve heart function,especialy diastolic function.
【CateGory Index】: R544.1;R541.6
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